Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-02-006 / 552-02-006 ISMRM Abstract

Imaging of perivascular space abnormality in SVD with high resolution T2* at 3T

Primary: Analysis Methods - Image Enhancement
Secondary: Acquisition & Reconstruction - Quantitative Imaging: head and neck
552-02-006 · Quantitative Imaging: Relaxometry, Multiparametric, MR Fingerprinting, and Synthetic MRI · Wednesday, 13 May, 1:40 PM–3:16 PM · Power Pitch Theatre 2
552-02-006 · Quantitative Imaging: Relaxometry, Multiparametric, MR Fingerprinting, and Synthetic MRI · Wednesday, 13 May, 1:40 PM–3:16 PM · Power Pitch Theatre 2
Keywords: Neurodegeneration Aging Alzheimer's Disease Neuroinflammation Perivascular spaces (PVS)
Accepted
Sangam Kanekar 1, Rommy Elyan1, Jianli Wang1, Anupa Ekanayake1, Senal D Peiris1, Ran Pang, Deepak Kalra2, William Jens2, Prasanna Karunanayaka1, Paul Eslinger2, Scott Hwang1, Qing Yang3
1Radiology, The Pennsylvania State University, Hershey, Pennsylvania, United States of America
2Neurology, The Pennsylvania State University, Hershey, Pennsylvania, United States of America
3Neurosurgery, The Pennsylvania State University, Hershey, Pennsylvania, United States of America
Presenting Author: Sangam Kanekar

Synopsis

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References

1. Yang, Q. X., Demeure, R. J., Dardzinski, B. J., Arnold, B. W., & Smith, M. B. (1999). Multiple echo frequency-domain image contrast: improved signal-to-noise ratio and T2 (T2*) weighting. Magnetic resonance in medicine, 41(2), 423–428. https://doi.org/10.1002/(sici)1522-2594(199902)41:2<423::aid-mrm30>3.0.co;2-m [doi]
2. Ma, Q., Ries, M., Decker, Y., Müller, A., Riner, C., Bücker, A., Fassbender, K., Detmar, M., & Proulx, S. T. (2019). Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain. Acta neuropathologica, 137(1), 151–165. https://doi.org/10.1007/s00401-018-1916-x [doi]
3. Ineichen, B. V., Okar, S. V., Proulx, S. T., Engelhardt, B., Lassmann, H., & Reich, D. S. (2022). Perivascular spaces and their role in neuroinflammation. Neuron, 110(21), 3566–3581. https://doi.org/10.1016/j.neuron.2022.10.024 [doi]
4. Voorter, P. H. M., van Dinther, M., Jansen, W. J., Postma, A. A., Staals, J., Jansen, J. F. A., van Oostenbrugge, R. J., van der Thiel, M. M., & Backes, W. H. (2024). Blood-Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights. Journal of magnetic resonance imaging : JMRI, 59(2), 397–411. https://doi.org/10.1002/jmri.28989 [doi]
5. Hong, H., Tozer, D. J., Chen, Y., Brown, R. B., Low, A., & Markus, H. S. (2025). Perivascular space dysfunction in cerebral small vessel disease is related to neuroinflammation. Brain : a journal of neurology, 148(5), 1540–1550. https://doi.org/10.1093/brain/awae357 [doi]
6. Shulyatnikova, T., & Hayden, M. R. (2023). Why Are Perivascular Spaces Important?. Medicina (Kaunas, Lithuania), 59(5), 917. https://doi.org/10.3390/medicina59050917 [doi]
7. Solé-Guardia, G., Li, H., Willemse, L., Lebenberg, J., Jouvent, E., & Tuladhar, A. M. (2025). Imaging brain fluid dynamics and waste clearance involving perivascular spaces in cerebral small vessel disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 21(4), e70212. https://doi.org/10.1002/alz.70212 [doi]
8. Sepehrband, F., Barisano, G., Sheikh-Bahaei, N., Cabeen, R. P., Choupan, J., Law, M., & Toga, A. W. (2019). Image processing approaches to enhance perivascular space visibility and quantification using MRI. Scientific reports, 9(1), 12351. https://doi.org/10.1038/s41598-019-48910-x [doi]
9. Barisano, G., Law, M., Custer, R. M., Toga, A. W., & Sepehrband, F. (2021). Perivascular Space Imaging at Ultrahigh Field MR Imaging. Magnetic resonance imaging clinics of North America, 29(1), 67–75. https://doi.org/10.1016/j.mric.2020.09.005 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/552-02-006