Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
563-01-004 ISMRM Abstract

Changes in White matter and total vessel volume are linked to treatment remission in major depressive disorder

Primary: Neuro - Psychiatric Disorders
Secondary: Neuro - White Matter
563-01-004 · Novel Neuro Applications · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row D
Keywords: Treatment Response Magnetic Resonance Imaging (MRI) Major depressive disorder Volumetric segmentation Antidepressant therapy
Accepted
Uma Sharma1, Vishwa Rawat2, Deepti Upadhyay2, Gagan Hans3
1Department of Nuclear Magnetic Resonance (NMR), All India Institute of Medical Sciences, New Delhi, India
2Department of NMR, All India Institute of Medical Sciences, New Delhi, India
3Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India
Presenting Author: Durgesh K Dwivedi

Synopsis

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References

1. Khin NA, Chen YF, Yang Y, Yang P, Laughren TP. Exploratory analyses of efficacy data from major depressive disorder trials submitted to the US Food and Drug Administration in support of new drug applications. J Clin Psychiatry. 2011;72(04):464-472. doi:10.4088/jcp.10m06191. [doi]
2. Yüksel D, Engelen J, Schuster V, et al. Longitudinal brain volume changes in major depressive disorder. J Neural Transm. 2018;125(10):1433-1447. doi:10.1007/s00702-018-1919-8. [doi]
3. Yang X, Kumar P, Wang M, et al. Antidepressant treatment-related brain activity changes in remitted major depressive disorder. Psychiatry Res. Neuroimaging. 2023; 330:111601. doi: 10.1016/j.pscychresns.2023.111601. [doi]
4. Agarwal N, Carare RO. Cerebral vessels: An overview of anatomy, physiology, and role in the drainage of fluids and solutes. Front. Neurol. 2021;11. doi:10.3389/fneur.2020.611485 [doi]
5. Taylor WD, Aizenstein HJ, Alexopoulos GS. The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol. Psychiatry. 2013;18(9):963-974. doi:10.1038/mp.2013.20. [doi]
6. He E, Liu M, Gong S, Fu X, Han Y, Deng F. White matter alterations in depressive disorder. Front. Immunol. 2022;13. doi:10.3389/fimmu.2022.826812. [doi]
7. Purkayastha S, Fadar O, Mehregan A, et al. Impaired Cerebrovascular Hemodynamics are Associated with Cerebral White Matter Damage. J. Cereb. Blood Flow Metab. 2013;34(2):228-234. doi:10.1038/jcbfm.2013.180. [doi]
8. Vreeburg SA, Hoogendijk WJG, Van Pelt J, et al. Major depressive Disorder and Hypothalamic-Pituitary-Adrenal axis activity. Arch Gen Psychiatry. 2009;66(6):617. doi:10.1001/archgenpsychiatry.2009.50. [doi]

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http://echo.ismrm.org/p/ISMRM2026/563-01-004