362-03-001 ISMRM Abstract

Elevated Serum CCL11 Is Associated with White Matter Microstructural and Tissue Property Changes in Schizophrenia

Primary: Neuro - Psychiatric Disorders

Secondary: Contrast Mechanisms - Magnetization Transfer

362-03-001 · Neuroimaging Signatures Across the Psychiatric Spectrum · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row C

Keywords: Neuroinflammation Myelin Schizophrenia Quantitative Magnetization Transfer Multi-dimensional Diffusion Encoding

Accepted

Khin Khin Tha ^1,2, Maho Kitagawa^1,2, Atsuhito Toyomaki³, Jakob Assländer^4,5, Sebastian Flassbeck^4,5, Kentaro Nishigami², Samo Lasic⁶, Shuhei Ishikawa³, Karin Bryskhe⁷, Yuta Urushibata⁸, Naoki Hashimoto³

¹Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sappro, Japan

²Laboratory for Biomarker Imaging Science, Graduate School of Biomedical Science and Engineering, Hokkaido University, Sappro, Japan

³Department of Psychiatry, Faculty of Medicine, Hokkaido University, Sappro, Japan

⁴The Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, United States of America

⁵Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, United States of America

⁶Department of Diagnostic Radiology, Lund University, Lund, Sweden

⁷Random Walk Imaging, Lund, Sweden

⁸Siemens Healthcare K.K., Tokyo, Japan

Presenting Author: Khin Khin Tha

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References

1. Owen MJ, Sawa A, Mortensen PB. Schizophrenia. Lancet. 2016; 388: 86–97. doi: 10.1016/S0140-6736(15)01121-6 [doi]

2. Valdés-Tovar M, Rodríguez-Ramírez AM, Rodríguez-Cárdenas L, Sotelo-Ramírez CE, Camarena B, Sanabrais-Jiménez MA, Solís-Chagoyán H, Argueta J, López-Riquelme GO. Insights into myelin dysfunction in schizophrenia and bipolar disorder. World J Psychiatry. 2022; 12: 264-285. doi: 10.5498/wjp.v12.i2.264 [doi]

3. Teixeira AL, Reis HJ, Nicolato R, Brito-Melo G, Correa H, Teixeira MM, Romano-Silva MA. Increased serum levels of CCL11/eotaxin in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32: 710-4. doi: 10.1016/j.pnpbp.2007.11.019 [doi]

4. Stuart MJ, Singhal G, Baune BT. Systematic Review of the Neurobiological Relevance of Chemokines to Psychiatric Disorders. Front Cell Neurosci. 2015; 9: 357. doi: 10.3389/fncel.2015.00357 [doi]

5. Szczepankiewicz F, Lasič S, van Westen D, Sundgren PC, Englund E, Westin CF, Ståhlberg F, Lätt J, Topgaard D, Nilsson M. Quantification of microscopic diffusion anisotropy disentangles effects of orientation dispersion from microstructure: applications in healthy volunteers and in brain tumors. Neuroimage. 2015; 104: 241–252. doi: 10.1016/j.neuroimage.2014.09.057 [doi]

6. Assländer J, Mao A, Marchetto E, Beck ES, Rosa F, Charlson RW, Shepherd TM, Flassbeck S. Unconstrained quantitative magnetization transfer imaging: Disentangling T1 of the free and semi-solid spin pools. Imaging Neurosci (Camb). 2024; 2: imag-2-00177. doi: 10.1162/imag_a_00177 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/362-03-001