Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
566-01-006 ISMRM Abstract

Ex vivo T2*-w MRI and Quantitative Susceptibility Mapping reflect histological iron accumulation in Frontotemporal Dementia

Accepted
Fieke Prinse 1,2, Lucia Giannini1, Marjolein Bulk1, Ernst Suidgeest2,3, Kyra Dijkstra4, Renee van Buuren1, Niels Dekker5, Marius Staring5, Chloe Najac2, John van Swieten1, Elise Dopper1, Harro Seelaar1, Louise van der Weerd2,6
1Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands
2C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands
3Central Animal Facility, Leiden University Medical Center, Leiden, Netherlands
4Department of Pathology, Leiden University Medical Center, Leiden, Netherlands
5Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands
6Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands
Presenting Author: Fieke Prinse

Synopsis

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References

1. Grossman M, Seeley WW, Boxer AL, Hillis AE, Knopman DS, Ljubenov PA, Miller B, Piguet O, Rademakers R, Whitwell JL, Zetterberg H, van Swieten JC. Frontotemporal lobar degeneration. Nat Rev Dis Primers. 2023 Aug 10;9(1):40. doi: 10.1038/s41572-023-00447-0. PMID: 37563165. [doi] [pmid]
2. Tisdall MD, Ohm DT, Lobrovich R, Das SR, Mizsei G, Prabhakaran K, Ittyerah R, Lim S, McMillan CT, Wolk DA, Gee J, Trojanowski JQ, Lee EB, Detre JA, Yushkevich P, Grossman M, Irwin DJ. Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology. Neuroimage Clin. 2022;33:102913. doi: 10.1016/j.nicl.2021.102913. Epub 2021 Dec 14. PMID: 34952351; PMCID: PMC8715243. [doi] [pmid]
3. Giannini LAA, Bulk M, Kenkhuis B, Rajicic A, Melhem S, Hegeman-Kleinn I, Bossoni L, Suidgeest E, Dopper EGP, van Swieten JC, van der Weerd L, Seelaar H. Cortical iron accumulation in MAPT- and C9orf 72-associated frontotemporal lobar degeneration. Brain Pathol. 2023 Jul;33(4):e13158. doi: 10.1111/bpa.13158. Epub 2023 Mar 27. PMID: 36974379; PMCID: PMC10307524. [doi] [pmid]
4. Prinse, F.A.M, Giannini, L.A.A., Bulk, M., et al. (2024, May 4 - 9) Analysis of Iron Accumulation in MAPT- and C9orf72-associated frontotemporal lobar degeneration: QSM, T2*-w MRI, and histology [Digital Poster Presentation]. ISMRM 2024, Singapore, Singapore. DOI: https://doi.org/10.58530/2024/2616 [doi]
5. Smith SM. Fast robust automated brain extraction. Hum Brain Mapp. 2002 Nov;17(3):143-55. doi: 10.1002/hbm.10062. PMID: 12391568; PMCID: PMC6871816. [doi] [pmid]
6. Schofield MA, Zhu Y. Fast phase unwrapping algorithm for interferometric applications. Opt Lett. 2003 Jul 15;28(14):1194-6. doi: 10.1364/ol.28.001194. PMID: 12885018. [doi] [pmid]
7. Li W, Wu B, Liu C. Quantitative susceptibility mapping of human brain reflects spatial variation in tissue composition. Neuroimage. 2011 Apr 15;55(4):1645-56. doi: 10.1016/j.neuroimage.2010.11.088. Epub 2011 Jan 9. PMID: 21224002; PMCID: PMC3062654. [doi] [pmid]
8. Liu T, Liu J, de Rochefort L, Spincemaille P, Khalidov I, Ledoux JR, Wang Y. Morphology enabled dipole inversion (MEDI) from a single-angle acquisition: comparison with COSMOS in human brain imaging. Magn Reson Med. 2011 Sep;66(3):777-83. doi: 10.1002/mrm.22816. Epub 2011 Apr 4. PMID: 21465541. [doi] [pmid]
9. Liu J, Liu T, de Rochefort L, Ledoux J, Khalidov I, Chen W, Tsiouris AJ, Wisnieff C, Spincemaille P, Prince MR, Wang Y. Morphology enabled dipole inversion for quantitative susceptibility mapping using structural consistency between the magnitude image and the susceptibility map. Neuroimage. 2012 Feb 1;59(3):2560-8. doi: 10.1016/j.neuroimage.2011.08.082. Epub 2011 Sep 8. PMID: 21925276; PMCID: PMC3254812. [doi] [pmid]
10. Liu Z, Spincemaille P, Yao Y, Zhang Y, Wang Y. MEDI+0: Morphology enabled dipole inversion with automatic uniform cerebrospinal fluid zero reference for quantitative susceptibility mapping. Magn Reson Med. 2018 May;79(5):2795-2803. doi: 10.1002/mrm.26946. Epub 2017 Oct 11. PMID: 29023982; PMCID: PMC5821583. [doi] [pmid]
11. van Duijn S, Nabuurs RJ, van Duinen SG, Natté R. Comparison of histological techniques to visualize iron in paraffin-embedded brain tissue of patients with Alzheimer's disease. J Histochem Cytochem. 2013 Nov;61(11):785-92. doi: 10.1369/0022155413501325. Epub 2013 Jul 25. PMID: 23887894; PMCID: PMC3808575. [doi] [pmid]
12. K. Ntatsis, N. Dekker, V. Valk, T. Birdsong, D. Zukić, S. Klein, M Staring, M McCormick, "itk-elastix: Medical image registration in Python", Proceedings of the 22nd Python in Science Conference, pp. 101 - 105, 2023, https://doi.org/10.25080/gerudo-f2bc6f59-00d. [doi]
13. Shamonin DP, Bron EE, Lelieveldt BP, Smits M, Klein S, Staring M; Alzheimer's Disease Neuroimaging Initiative. Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer's disease. Front Neuroinform. 2014 Jan 16;7:50. doi: 10.3389/fninf.2013.00050. PMID: 24474917; PMCID: PMC3893567. [doi] [pmid]
14. Schindelin, J., Arganda-Carreras, I., Frise, E. et al. Fiji: an open-source platform for biological-image analysis. Nat Methods 9, 676–682 (2012). https://doi.org/10.1038/nmeth.2019 [doi]

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