Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-02-002 ISMRM Abstract

Elevated Cerebral Oxygen Extraction Fraction in Parkinson’s Disease Correlates with Motor Impairment Severity

Primary: Neuro - Parkinson's Disease
Secondary: Contrast Mechanisms - Oxygenation
369-02-002 · Imaging Parkinson’s Disease: Multimodal Biomarkers of Progression and Phenotype · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row J
Keywords: Parkinson's Disease Oxygen extraction fraction Brain metabolism Cerebral Oxygen Metabolism Motor Impairment
Accepted
Huseyin E Candan 1, Dongkyu Lee2,3, Hansol Lee3,4, Jae-Hyeok Lee5, Junghun Cho6, HyungJoon Cho3
1Graduate School of Health Science and Technology, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
2Brain Tech Center, Korean Brain Research Instititute, Daegu, Korea, Republic of
3Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
4Deaprtment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
5Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of
6Biomedical Engineering, George Washington University, Washington, United States of America
Presenting Author: Huseyin E Candan

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References

1. Bloem BR, Okun MS and Klein C. Parkinson's disease. The Lancet 2021; 397: 2284-2303.
2. Beach TG and Adler CH. Importance of low diagnostic Accuracy for early Parkinson's disease. Mov Disord 2018; 33: 1551-1554. 20181004. DOI: 10.1002/mds.27485. [doi]
3. Meles SK, Teune LK, de Jong BM, et al. Metabolic imaging in Parkinson disease. Journal of Nuclear Medicine 2017; 58: 23-28.
4. Cho J, Ma Y, Spincemaille P, et al. Cerebral oxygen extraction fraction: comparison of dual‐gas challenge calibrated BOLD with CBF and challenge‐free gradient echo QSM+ qBOLD. Magnetic resonance in medicine 2021; 85: 953-961.
5. Pelizzari L, Laganà MM, Rossetto F, et al. Cerebral blood flow and cerebrovascular reactivity correlate with severity of motor symptoms in Parkinson’s disease. Therapeutic Advances in Neurological Disorders 2019; 12: 1756286419838354.
6. Goetz CG, Tilley BC, Shaftman SR, et al. Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): scale presentation and clinimetric testing results. Movement disorders: official journal of the Movement Disorder Society 2008; 23: 2129-2170.
7. Hoehn MM and Yahr MD. Parkinsonism: onset, progression, and mortality. Neurology 1967; 17: 427-427.
8. Arevalo-Rodriguez I, Smailagic N, Roqué-Figuls M, et al. Mini‐Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI). Cochrane Database of Systematic Reviews 2021.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-02-002