Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
331-01-005 / 331-01-005 ISMRM Abstract

Impact of radiotherapy on brain growth and neurometabolites in a juvenile rodent model

Primary: Neuro - Other Neurodegeneration
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
331-01-005 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
331-01-005 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
Keywords: Radiotherapy Segmentation Spectroscopy Brain Development Animal Model
Accepted
Shannon Helsper1,2, Uwe Himmelreich 1,2, Edmond Sterpin3
1Biomedical MRI, KU Leuven, Leuven, Belgium
2Department of Imaging & Pathology, KU Leuven, Leuven, Belgium
3Laboratory of Experimental Radiotherapy, KU Leuven, Leuven, Belgium
Presenting Author: Uwe Himmelreich

Synopsis

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References

1. Lumniczky K, Szatmári T, Sáfrány G. Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain. Front Immunol. 2017;8(5):1. doi:10.3389/FIMMU.2017.00517 [doi]
2. Makale MT, McDonald CR, Hattangadi-Gluth JA, Kesari S. Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours. Nat Rev Neurol. 2017;13(1):52-64. doi:10.1038/nrneurol.2016.185 [doi]
3. Zanni G, Zhou K, Riebe I, et al. Irradiation of the Juvenile Brain Provokes a Shift from Long-Term Potentiation to Long-Term Depression. Dev Neurosci. 2015;37(3):263-272. doi:10.1159/000430435 [doi]
4. Baudou É, Ryan JL, Tseng J, et al. Repairing Myelin After Irradiated Pediatric Brain Tumor: A Magnetization Transfer Imaging Analysis. Pediatr Blood Cancer. 2025;72(9). doi:10.1002/PBC.31838 [doi]
5. Riva M, Wouters R, Sterpin E, et al. Radiotherapy, Temozolomide, and Antiprogrammed Cell Death Protein 1 Treatments Modulate the Immune Microenvironment in Experimental High-Grade Glioma. Neurosurgery. 2021;88(2):E205-E215. doi:10.1093/NEUROS/NYAA421 [doi]
6. Tustison NJ, Avants BB, Cook PA, et al. N4ITK: Improved N3 Bias Correction. IEEE Trans Med Imaging. 2010;29(6):1310. doi:10.1109/TMI.2010.2046908 [doi]
7. Goerzen D, Fowler C, Devenyi GA, et al. An MRI-Derived Neuroanatomical Atlas of the Fischer 344 Rat Brain. Sci Rep. 2020;10(1):1-13. doi:10.1038/S41598-020-63965-X [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/331-01-005