460-02-005 ISMRM Abstract

PDH and PC Dysfunction in Glucose Metabolism Underlies Neuronal Energy Deficit in Alzheimer’s Disease

Primary: Neuro - Alzheimer's Disease

Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods

460-02-005 · From Bench to Bedside: All About the Brain in Health and Alzheimer’s Disease · Tuesday, 12 May, 9:15 AM–10:10 AM · Digital Posters Row A

Keywords: Cognitive decline Pentose Phosphate Pathway 13C NMR 5xFAD 2-13C-Glucose

Accepted

Anant B Patel ¹, Chaynita Dashora¹

¹NMR MICROIMAGING AND SPECTROSCOPY, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India

Presenting Author: Anant B Patel

Synopsis

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References

1. Karch CM, Cruchaga C, Goate AM. Alzheimer's disease genetics: from the bench to the clinic. Neuron. 2014;83(1):11-26.

2. Mosconi L, Pupi A, De Leon MJ. Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer’s disease. Ann NY Acad Sci. 2009;1147:180–95.

3. Yuan Y, Zhao G, Zhao Y. Dysregulation of energy metabolism in Alzheimer's disease. J Neurol. 2024;272(1):2.

4. Brekke EM, Morken TS, Widerøe M, Håberg AK, Brubakk AM, Sonnewald U. The pentose phosphate pathway and pyruvate carboxylation after neonatal hypoxic-ischemic brain injury. J Cereb Blood Flow Metab. 2014;34(4):724-34.

5. Tiwari V, Patel AB. Pyruvate carboxylase and pentose phosphate fluxes are reduced in AβPP-PS1 mouse model of Alzheimer's disease: a ¹³C NMR study. J Alzheimers Dis. 2014;41(2):387-99.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/460-02-005