Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
363-03-008 MRI in Clinical Practice Abstract

Mp2rage-based quantitative MRI enhances volumetric and relaxometric assessment in pediatric mitochondrial cytopathies.

Primary: Pediatrics - Rare Disease
Secondary: Neuro - Other Neurodegeneration
363-03-008 · MRI in Clinical Practice: Diagnostic Applications, Quantitative Imaging, and Emerging Techniques · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row D
Keywords: Pediatric Brain Imaging Brain tissue segmentation Mitochondrial metabolism Quantitative MRI metrics
Accepted
Paul Chataigner1, Marine Guichard2, Pierre Castelnau2, Samantha Gerrie3, Till Huelnhagen4, Bénédicte Maréchal 5,6,7, Gian Franco Piredda8,9,10, Jean Philippe Cottier11, Baptiste Morel12,13
1Clocheville Hospital, University hospital of Tours, Tours, France
2Pediatric Neurology, Clocheville Hospital, University hospital of Tours, Tours, France
3Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, Canada
4Research & Clinical Translation, Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany
5Swiss Innovation Hub, Siemens Healthineers International AG, Lausanne, Switzerland
6LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
7Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
8Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
9Swiss Innovation Hub, Siemens Healthineers International AG, Switzerland
10CHUV | Lausanne University Hospital, Switzerland
11Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, Tours, France
12Department of Radiology, University of British Columbia, Vancouver, Canada
13Pediatric Radiology, Clocheville Hospital, University hospital of Tours, Tours, France
Presenting Author: Bénédicte Maréchal

Synopsis

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References

1. Muñoz A, Mateos F, Simón R, et al (1999) Mitochondrial diseases in children: neuroradiological and clinical features in 17 patients. Neuroradiology 41:920–928. https://doi.org/10.1007/s002340050868 [doi]
2. Saneto RP, Friedman SD, Shaw DWW (2008) Neuroimaging of mitochondrial disease. Mitochondrion 8:396–413. https://doi.org/10.1016/j.mito.2008.05.003 [doi]
3. Kim IO, Kim JH, Kim WS, et al (1996) Mitochondrial myopathy-encephalopathy-lactic acidosis-and strokelike episodes (MELAS) syndrome: CT and MR findings in seven children. AJR Am J Roentgenol 166:641–645. https://doi.org/10.2214/ajr.166.3.8623642 [doi]
4. Lu J, Huang Y (2013) Childhood mitochondrial encephalomyopathies: clinical course, diagnosis, neuroimaging findings, mtDNA mutations and outcome in six children. Ital J Pediatr 39:60. https://doi.org/10.1186/1824-7288-39-60 [doi]
5. Münch J, Prasuhn J, Laugwitz L, et al (2023) Neuroimaging in Primary Coenzyme-Q10-Deficiency Disorders. Antioxid Basel Switz 12:718. https://doi.org/10.3390/antiox12030718 [doi]
6. Valanne L, Ketonen L, Majander A, et al (1998) Neuroradiologic findings in children with mitochondrial disorders. AJNR Am J Neuroradiol 19:369–377
7. Morel B, Piredda GF, Cottier J-P, et al (2021) Normal volumetric and T1 relaxation time values at 1.5 T in segmented pediatric brain MRI using a MP2RAGE acquisition. Eur Radiol 31:1505–1516. https://doi.org/10.1007/s00330-020-07194-w [doi]
8. De Beaurepaire I, Grévent D, Rio M, et al (2018) High predictive value of brain MRI imaging in primary mitochondrial respiratory chain deficiency. J Med Genet 55:378–383. https://doi.org/10.1136/jmedgenet-2017-105094 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/363-03-008