464-03-008 ISMRM Abstract

Lower cerebral oxygen utilization associates with poorer cognitive and motor function in progressive supranuclear palsy

Primary: Neuro - Other Neurodegeneration

Secondary: Contrast Mechanisms - Oxygenation

464-03-008 · Neurodegenerative Diseases · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row E

Keywords: Oxygen extraction fraction Progressive supranuclear palsy Quantitative Susceptibility Mapping (QSM) CMRO2

Accepted

Na Wang¹, Pu-Yeh Wu ², Xueling Liu¹

¹Huashan Hospital, Fudan University, China

²GE Healthcare, Beijing, China

Presenting Author: Pu-Yeh Wu

Synopsis

Motivation:

Goals:

Approach:

Results:

Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

References

1. Robb WH et al. Lower cerebral oxygen utilization is associated with Alzheimer's disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers. J Cereb Blood Flow Metab. 2022.

2. Ishii K et al. Decreased medial temporal oxygen metabolism in Alzheimer's disease shown by PET. J Nucl Med. 1996.

3. Ito H et al. Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with 15O-labelled carbon dioxide or water, carbon monoxide and oxygen: a multicentre study in Japan. Eur J Nucl Med Mol Imaging. 2004.

4. Jiang D and Lu H. Cerebral oxygen extraction fraction MRI: Techniques and applications. Magn Reson Med. 2022.

5. Stadlbauer A et al. Development of a Non-invasive Assessment of Hypoxia and Neovascularization with Magnetic Resonance Imaging in Benign and Malignant Breast Tumors: Initial Results. Mol Imaging Biol. 2019.

6. Cho J et al. Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with 15O PET in healthy adults. J Cereb Blood Flow Metab. 2021.

7. Yan S et al. Spatiotemporal patterns of brain iron-oxygen metabolism in patients with Parkinson's disease. Eur Radiol. 2024.

8. Yan S et al. Potential separation of multiple system atrophy and Parkinson's disease by susceptibility-derived components. Neuroimage. 2025.

9. Liu FT et al. Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI). 18F-Florzolotau PET imaging captures the distribution patterns and regional vulnerability of tau pathology in progressive supranuclear palsy. Eur J Nucl Med Mol Imaging. 2023.

10. Cho J et al. QQ-NET - using deep learning to solve quantitative susceptibility mapping and quantitative blood oxygen level dependent magnitude (QSM+qBOLD or QQ) based oxygen extraction fraction (OEF) mapping. Magn Reson Med. 2021.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/464-03-008