1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue #1095, Wuhan, China
2Clinical Science, Philips Healthcare, Chengdu, China
3Philips Healthcare (Beijing), Beijing, China
4Clinical and Technical Support, Philips Healthcare (Beijing), Beijing, China
5Clinical & Technique Support, Philips Healthcare (Beijing), Beijing, China
Presenting Author: Shaolong Wu
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1. Correale J, Solomon AJ, Cohen JA et al. Differential diagnosis of suspected multiple sclerosis: global health considerations. Lancet Neurol (2024); 23: 1035–1049. doi:10.1016/S1474-4422(24)00256-4 [doi]
2. Wingerchuk DM, Lucchinetti CF. Neuromyelitis Optica Spectrum Disorder. N Engl J Med (2022); 387: 631–639. doi:10.1056/NEJMra1904655 [doi]
3. Cacciaguerra L, Rocca MA, Filippi M. Understanding the Pathophysiology and Magnetic Resonance Imaging of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders. Korean J Radiol (2023); 24: 1260–1283. doi:10.3348/kjr.2023.0360 [doi]
4. Chen X, Roberts N, Zheng Q et al. Comparison of diffusion tensor imaging parameters in white matter tracts of patients with MS and NMOSD. Eur Radiol (2024); 34: 5263–5275. doi:10.1007/s00330-023-10550-1 [doi]
5. Bilgic B, Costagli M, Chan KS et al. Recommended implementation of quantitative susceptibility mapping for clinical research in the brain. Magn Reson Med (2024); 91: 1834–1862. doi:10.1002/mrm.30006 [doi]
6. Bjørklund G, Wallace DR, Hangan T et al. Cerebral iron accumulation in multiple sclerosis: Pathophysiology and therapeutic implications. Autoimmun Rev (2025); 24: 103741. doi:10.1016/j.autrev.2025.103741 [doi]
7. Shin HG, Lee J, Yun YH et al. χ-separation: Magnetic susceptibility source separation toward iron and myelin mapping in the brain. Neuroimage (2021); 240: 118371. doi:10.1016/j.neuroimage.2021.118371 [doi]
8. Dimov AV, Gillen KM, Nguyen TD et al. Magnetic Susceptibility Source Separation Solely from Gradient Echo Data: Histological Validation. Tomography (2022); 8: 1544–1551. doi:10.3390/tomography8030127 [doi]
9. Kim W, Shin HG, Lee H et al. χ-Separation Imaging for Diagnosis of Multiple Sclerosis versus Neuromyelitis Optica Spectrum Disorder. Radiology (2023); 307: e220941. doi:10.1148/radiol.220941 [doi]
10. Müller J, Lu PJ, Cagol A et al. Quantifying Remyelination Using χ-Separation in White Matter and Cortical Multiple Sclerosis Lesions. Neurology (2024); 103: e209604. doi:10.1212/WNL.0000000000209604 [doi]
11. Hametner S, Wimmer I, Haider L et al. Iron and neurodegeneration in the multiple sclerosis brain. Ann Neurol (2013); 74: 848–861. doi:10.1002/ana.23974 [doi]
12. Giampiccolo D, Herbet G, Duffau H. The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy. Brain (2025); 148: 1507–1525. doi:10.1093/brain/awaf055 [doi]
13. Jeong IH, Choi JY, Kim SH et al. Comparison of myelin water fraction values in periventricular white matter lesions between MS and NMOSD. Mult Scler (2016); 22: 1616–1620. doi:10.1177/1352458516636247 [doi]
14. Kutzelnigg A, Lucchinetti CF, Stadelmann C et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain (2005); 128: 2705–2712. doi:10.1093/brain/awh641 [doi]
15. Sati P, Oh J, Constable RT et al. The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis. Nat Rev Neurol (2016); 12: 714–722. doi:10.1038/nrneurol.2016.166 [doi]
16. Absinta M, Sati P, Schindler M et al. Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis lesions. J Clin Invest (2016); 126: 2597–2609. doi:10.1172/JCI86198 [doi]
17. Zivadinov R, Tavazzi E, Bergsland N et al. Brain Iron at Quantitative MRI Is Associated with Disability in Multiple Sclerosis. Radiology (2018); 289: 487–496. doi:10.1148/radiol.2018180136 [doi]