Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
564-02-010 ISMRM Abstract

UTE/ZTE MRI-derived Synthetic CT for Transcranial Focused Ultrasound Planning: Validation in Non-Human Primates and Humans

Primary: Interventional - MR-Guided Focused Ultrasound
Secondary: Analysis Methods - Image Synthesis and Translation
564-02-010 · Interventional MRI: General · Wednesday, 13 May, 9:15 AM–10:10 AM · Digital Posters Row E
Keywords: Human and non-human primates Image synthesis UTE-MRI Transcranial focused ultrasound Mamba
Accepted
Dong Liu1, Zhuoyao Xin2,3, Sergio Jimenez Gambin4, Fotis Tsitsos4, Kay C Igwe 4, Jinfu Niu4, Elisa E Konofagou4,5, Vincent P Ferrera1,6, Jia Guo1,4,7
1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States of America
2F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, United States of America
3Department of Biomedical Engineering, Johns Hopkins University, Baltimore, United States of America
4Department of Biomedical Engineering, Columbia University, New York, United States of America
5Department of Radiology, Columbia University, New York, United States of America
6Department of Neuroscience, Columbia University, New York, United States of America
7Department of Psychiatry, Columbia University, New York, United States of America
Presenting Author: Kay C Igwe

Synopsis

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References

1. Munoz, F., Meaney, A., Gross, A., Liu, K., Pouliopoulos, A.N., Liu, D., Konofagou, E.E. and Ferrera, V.P., 2022. Long term study of motivational and cognitive effects of low-intensity focused ultrasound neuromodulation in the dorsal striatum of nonhuman primates. Brain stimulation, 15(2), pp.360-372. doi: 10.1016/j.brs.2022.01.014 [doi]
2. Verhagen, L., Gallea, C., Folloni, D., Constans, C., Jensen, D.E., Ahnine, H., Roumazeilles, L., Santin, M., Ahmed, B., Lehericy, S. and Klein-Flügge, M.C., 2019. Offline impact of transcranial focused ultrasound on cortical activation in primates. Elife, 8, p.e40541. doi: 10.7554/eLife.40541 [doi]
3. Koh, H., Park, T.Y., Chung, Y.A., Lee, J.H. and Kim, H., 2021. Acoustic simulation for transcranial focused ultrasound using GAN-based synthetic CT. IEEE Journal of Biomedical and Health Informatics, 26(1), pp.161-171. doi: 10.1109/JBHI.2021.3103387 [doi]
4. Yaakub, S.N., White, T.A., Kerfoot, E., Verhagen, L., Hammers, A. and Fouragnan, E.F., 2023. Pseudo-CTs from T1-weighted MRI for planning of low-intensity transcranial focused ultrasound neuromodulation: An open-source tool. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 16(1), pp.75-78. doi: 10.1016/j.brs.2023.01.838 [doi]
5. Miscouridou, M., Pineda-Pardo, J.A., Stagg, C.J., Treeby, B.E. and Stanziola, A., 2022. Classical and learned MR to pseudo-CT mappings for accurate transcranial ultrasound simulation. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 69(10), pp.2896-2905. doi: 10.1109/TUFFC.2022.3198522 [doi]
6. Liu, D., Xin, Z., Ji, R., Tsitsos, F., Jiménez-Gambín, S., Konofagou, E.E., Ferrera, V.P. and Guo, J., 2024, May. Enhancing Transcranial Focused Ultrasound Treatment Planning With Synthetic CT from Ultra-Short Echo Time (UTE) MRI: A Multi-Task Deep Learning Approach. In 2024 IEEE International Symposium on Biomedical Imaging (ISBI) (pp. 1-5). IEEE. doi: 10.1109/ISBI56570.2024.10635176. [doi]

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http://echo.ismrm.org/p/ISMRM2026/564-02-010