Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
564-04-004 ISMRM Abstract

NODDI and DTI-ALPS Reveal White Matter Deficits and Glymphatic impairment in First-Episode Adolescent MDD

Primary: Brain Function and fMRI - fMRI & Neuromodulation
Secondary: Neuro - Psychiatric Disorders
564-04-004 · Imaging Depression · Wednesday, 13 May, 2:35 PM–3:30 PM · Digital Posters Row E
Accepted
Laiyang Ma 1, Yuhui Xiong2, Jing Zhang3
1Department of Magnetic Resonance, Lanzhou, China
2GE HealthCare MR Research, Beijing, China
3Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou, China, Department of Magnetic Resonance, Lanzhou, China
Presenting Author: Laiyang Ma

Synopsis

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References

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2. Wu Q, Chen J, Yang X, Zhang X, He W, Xia J. Associations of ventriculomegaly and white matter hyperintensities with glymphatic dysfunction in idiopathic normal pressure hydrocephalus. Eur Radiol. 2025 Jul;35(7):4315-4324. doi: 10.1007/s00330-024-11320-3. Epub 2025 Jan 21. PMID: 39836203; PMCID: PMC12166017. [doi] [pmid]
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4. Liu X, Hao J, Yao E, Cao J, Zheng X, Yao D, Zhang C, Li J, Pan D, Luo X, Wang M, Wang W. Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems. Brain Behav Immun. 2020 Oct;89:357-370. doi: 10.1016/j.bbi.2020.07.022. Epub 2020 Jul 24. PMID: 32717402. [doi] [pmid]
5. Yang C, Tian S, Du W, Liu M, Hu R, Gao B, Pan T, Song Q, Liu T, Wang W, Zhang H, Miao Y. Glymphatic function assessment with diffusion tensor imaging along the perivascular space in patients with major depressive disorder and its relation to cerebral white-matter alteration. Quant Imaging Med Surg. 2024 Sep 1;14(9):6397-6412. doi: 10.21037/qims-24-510. Epub 2024 Aug 19. PMID: 39281139; PMCID: PMC11400689. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/564-04-004