Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
451-02-015 / 451-02-015 ISMRM Abstract

Acute Decreased Perfusion in the Brain Causes Compensatory Decrease in Stiffness

Primary: Contrast Mechanisms - Elastography
Secondary: Contrast Mechanisms - Arterial Spin Labelling
451-02-015 · Advances in Contrast Mechanisms · Tuesday, 12 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
451-02-015 · Advances in Contrast Mechanisms · Tuesday, 12 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
Keywords: Brain Cerebral blood flow (CBF) Neurofluid coupling Pseudocontinuous Arterial Spin Labeling Magnetic Resonance Elastography (MRE)
Accepted
Mary K Kramer 1, Gabriella L Dunay1,2,3, Fiona M Horvat4, Nathan T Romberger4, Christopher R Martens4, Curtis L Johnson1
1Biomedical Engineering, University of Delaware, Newark, United States of America
2Department of Biomedical Engineering, Vanderbilt University, Nashville, United States of America
3Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, United States of America
4Kinesiology and Applied Physiology, University of Delaware, Newark, United States of America
Presenting Author: Mary K Kramer

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References

1. Muthupillai, R. et al. Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. Science. 269, 1854–1857 (1995). doi:10.1126/science.7569924 [doi]
2. Schwarb, H. et al. Aerobic fitness, hippocampal viscoelasticity, and relational memory performance. Neuroimage. 153, 179–188 (2017). doi:10.1016/j.neuroimage.2017.03.061 [doi]
3. Sandroff, B. M., Johnson, C. L. & Motl, R. W. Exercise training effects on memory and hippocampal viscoelasticity in multiple sclerosis: a novel application of magnetic resonance elastography. Neuroradiology 59, 61–67 (2017). doi:10.1007/s00234-016-1767-x [doi]
4. McIlvain, G. et al. Acute effects of high-intensity exercise on brain mechanical properties and cognitive function. Brain Imaging Behav. (2024) doi:10.1007/s11682-024-00873-y [doi]
5. Goswami, N., Blaber, A. P., Hinghofer-Szalkay, H. & Convertino, V. A. Lower body negative pressure: Physiological effects, applications, and implementation. Physiol. Rev. 99, 807–851 (2019). doi:10.1152/physrev.00006.2018 [doi]
6. Bronzwaer, A. S. G. T. et al. The cerebrovascular response to Lower-body negative pressure vs. head-up tilt. J. Appl. Physiol. 122, 877–883 (2017). doi:10.1152/japplphysiol.00797.2016 [doi]
7. Herthum, H. et al. Real-Time Multifrequency MR Elastography of the Human Brain Reveals Rapid Changes in Viscoelasticity in Response to the Valsalva Maneuver. Front. Bioeng. Biotechnol. 9, 1–12 (2021). doi:10.3389/fbioe.2021.666456 [doi]
8. Hetzer, S. et al. Hypercapnia increases brain viscoelasticity. J. Cereb. Blood Flow Metab. 39, 2445–2455 (2019). doi:10.1177/0271678X18799241 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/451-02-015