301-03-002 ISMRM Abstract

Multimodal MRI Assessment of Structural and Diffusion Alterations in a Non-Human Primate Model of Alzheimer’s Disease

Primary: Preclinical Animal & in vitro MR - Large Animals, Nonhuman Primates

Secondary: Neuro - Alzheimer's Disease

301-03-002 · Neuroimaging and Spectroscopy in Experimental Models · Monday, 11 May, 1:50 PM–3:40 PM · Hall 1A

Keywords: Alzheimer's Disease T2-weighted imaging Diffusion Tensor Imaging (DTI) Non-human primates

Accepted

Ching-Wen Chang ¹, Ssu-Ju Li¹, Boyi Qu², Yao-Wen Liang^1,3, Yu-Qian Ke¹, Cheng-Ru Yang^1,4, Ting-Chieh Chen¹, Zhi-Shin Cheng⁵, Yi-Ren Lin⁵, Yi-Duan Chen⁶, You-Yin Chen^1,3, Hsin-Yi Lai²

¹Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan

²Guangdong Institute of Intelligence Science and Technology, China

³Ph.D. Program In Medical Neuroscience, Taipei Medical University, Taipei, Taiwan

⁴National Yang Ming Chiao Tung University, Taipei, Taiwan

⁵School of Gerontology and Long-Term Care, Taipei Medical University, Taipei, Taiwan

⁶Department of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan

Presenting Author: Ching-Wen Chang

Synopsis

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References

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3. Tu, Z., Yan, S., Han, B., Li, C., Liang, W., Lin, Y., . . . Xu, H. (2023). Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys. Signal Transduction and Targeted Therapy, 8(1), 358.

4. Li, Y., & Gu, B. J. (2023). Non-human Primate Models of Alzheimer’s Disease. Journal of Exploratory Research in Pharmacology, 8(3), 199–221. doi:10.14218/jerp.2023.00006 [doi]

5. Beckman, D., Diniz, G. B., Ott, S., Hobson, B., Chaudhari, A. J., Muller, S., . . . Morrison, J. H. (2024). Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease. Alzheimers Dement, 20(8), 5198–5219. doi:10.1002/alz.13868 [doi]

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7. Wang, K. W., Zhang, G., & Kuo, M. H. (2023). Frontotemporal Dementia P301L Mutation Potentiates but Is Not Sufficient to Cause the Formation of Cytotoxic Fibrils of Tau. Int J Mol Sci, 24(19). doi:10.3390/ijms241914996 [doi]

8. Lewis, J., McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., . . . Yu, X. (2000). Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature genetics, 25(4), 402–405.

9. Madden, D. J., & Parks, E. L. (2016). Age Differences in Structural Connectivity: Diffusion Tensor Imaging and White Matter Hyperintensities. In R. Cabeza, L. Nyberg, & D. C. Park (Eds.), Cognitive Neuroscience of Aging: Linking Cognitive and Cerebral Aging (pp. 0): Oxford University Press.

10. Pelletier, A., Periot, O., Dilharreguy, B., Hiba, B., Bordessoules, M., Chanraud, S., . . . Catheline, G. (2015). Age-Related Modifications of Diffusion Tensor Imaging Parameters and White Matter Hyperintensities as Inter-Dependent Processes. Front Aging Neurosci, 7, 255. doi:10.3389/fnagi.2015.00255 [doi]

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http://echo.ismrm.org/p/ISMRM2026/301-03-002