569-06-007 ISMRM Abstract

Iron sensitivity of longitudinal and transverse relaxation rates in the post-mortem human brain

Primary: Contrast Mechanisms - Microstructure

Secondary: Contrast Mechanisms - Relaxometry

569-06-007 · Magnetization Transfer and Relaxometry · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row J

Keywords: Microstructure Quantitative MRI Ex-vivo brain imaging Brain IRON RELAXATION RATE mapping

Accepted

Anna Capponi ^1,2, Nikolaus Krebs³, Walter Goessler⁴, Eva Scheurer^5,6, Kathrin Yen⁷, Stefan Ropele¹, Alessandra Bertoldo², Christian Langkammer⁸

¹Department of Neurology, Medical University Graz, Graz, Austria

²Department of Information Engineering, University of Padova, Padova, Italy

³Psychiatric Service of the Health District of Bolzano, Bolzano, Italy

⁴Institute of Chemistry, University of Graz, Graz, Austria

⁵Health Department Basel-Stadt, Institute of Forensic Medicine, Basel, Austria

⁶Biomedical Engineering, Institute of Forensic Medicine, University of Basel,, Basel, Austria

⁷Institute of Forensic Medicine, University Hospital of Heidelberg, Heidelberg, Germany

⁸Department of Neurology, Medical University of Graz, Graz, Austria

Presenting Author: Anna Capponi

Synopsis

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References

1. Freeland-Graves, Jean & Proffitt, Michael. (2002). Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences. Second Edition By Robert Crichton (Université Catholique De Louvain, Belgium). J. Wiley & Sons: Chichester. 2001. xxi + 326 pp. $165.00. ISBN:0-471-49223-X. Journal of The American Chemical Society - J AM CHEM SOC. 124. 7636-7636. 10.1021/ja015379j. [doi]

2. HALLGREN B, SOURANDER P. The effect of age on the non-haemin iron in the human brain. J Neurochem. 1958 Oct;3(1):41-51. doi: 10.1111/j.1471-4159.1958.tb12607.x. PMID: 13611557. [doi] [pmid]

3. Ordidge RJ, Gorell JM, Deniau JC, Knight RA, Helpern JA. Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla. Magn Reson Med. 1994 Sep;32(3):335-41. doi: 10.1002/mrm.1910320309. PMID: 7984066. [doi] [pmid]

4. Langkammer C, Krebs N, Goessler W, Scheurer E, Ebner F, Yen K, Fazekas F, Ropele S. Quantitative MR imaging of brain iron: a postmortem validation study. Radiology. 2010 Nov;257(2):455-62. doi: 10.1148/radiol.10100495. Epub 2010 Sep 15. Erratum in: Radiology. 2011 Mar;258(3):962. PMID: 20843991. [doi] [pmid]

5. Yao B, Li TQ, Gelderen Pv, Shmueli K, de Zwart JA, Duyn JH. Susceptibility contrast in high field MRI of human brain as a function of tissue iron content. Neuroimage. 2009 Feb 15;44(4):1259-66. doi: 10.1016/j.neuroimage.2008.10.029. Epub 2008 Nov 5. Erratum in: Neuroimage. 2012 Sep;62(3):2173. PMID: 19027861; PMCID: PMC2670442. [doi] [pmid]

6. Ogg RJ, Steen RG. Age-related changes in brain T1 are correlated with iron concentration. Magn Reson Med. 1998 Nov;40(5):749-53. doi: 10.1002/mrm.1910400516. PMID: 9797159. [doi] [pmid]

7. Vymazal J, Hajek M, Patronas N, Giedd JN, Bulte JW, Baumgarner C, Tran V, Brooks RA. The quantitative relation between T1-weighted and T2-weighted MRI of normal gray matter and iron concentration. J Magn Reson Imaging. 1995 Sep-Oct;5(5):554-60. doi: 10.1002/jmri.1880050514. PMID: 8574041. [doi] [pmid]

8. Vymazal J, Brooks RA, Baumgarner C, Tran V, Katz D, Bulte JW, Bauminger R, Di Chiro G. The relation between brain iron and NMR relaxation times: an in vitro study. Magn Reson Med. 1996 Jan;35(1):56-61. doi: 10.1002/mrm.1910350108. PMID: 8771022. [doi] [pmid]

9. Steen RG, Reddick WE, Ogg RJ. More than meets the eye: significant regional heterogeneity in human cortical T1. Magn Reson Imaging. 2000 May;18(4):361-8. doi: 10.1016/s0730-725x(00)00123-5. PMID: 10788712. [doi] [pmid]

10. Rooney WD, Johnson G, Li X, Cohen ER, Kim SG, Ugurbil K, Springer CS Jr. Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo. Magn Reson Med. 2007 Feb;57(2):308-18. doi: 10.1002/mrm.21122. PMID: 17260370. [doi] [pmid]

11. Stüber C, Morawski M, Schäfer A, Labadie C, Wähnert M, Leuze C, Streicher M, Barapatre N, Reimann K, Geyer S, Spemann D, Turner R. Myelin and iron concentration in the human brain: a quantitative study of MRI contrast. Neuroimage. 2014 Jun;93 Pt 1:95-106. doi: 10.1016/j.neuroimage.2014.02.026. Epub 2014 Mar 6. PMID: 24607447. [doi] [pmid]

12. van der Weijden CWJ, Biondetti E, Gutmann IW, Dijkstra H, McKerchar R, de Paula Faria D, de Vries EFJ, Meilof JF, Dierckx RAJO, Prevost VH, Rauscher A. Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status. Brain. 2023 Apr 19;146(4):1243-1266. doi: 10.1093/brain/awac436. PMID: 36408715; PMCID: PMC10115240. [doi] [pmid]

13. Langkammer C, Krebs N, Goessler W, Scheurer E, Yen K, Fazekas F, Ropele S. Susceptibility induced gray-white matter MRI contrast in the human brain. Neuroimage. 2012 Jan 16;59(2):1413-9. doi: 10.1016/j.neuroimage.2011.08.045. Epub 2011 Aug 26. PMID: 21893208; PMCID: PMC3236994. [doi] [pmid]

14. Shepherd TM, Flint JJ, Thelwall PE, Stanisz GJ, Mareci TH, Yachnis AT, Blackband SJ. Postmortem interval alters the water relaxation and diffusion properties of rat nervous tissue--implications for MRI studies of human autopsy samples. Neuroimage. 2009 Feb 1;44(3):820-6. doi: 10.1016/j.neuroimage.2008.09.054. Epub 2008 Oct 19. PMID: 18996206; PMCID: PMC2836859. [doi] [pmid]

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