Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
465-03-008 ISMRM Abstract

Sciatic Nerve Fascicular Morphometry from High-resolution MRI as Biomarkers in Polyneuropathies

Primary: Neuro - Peripheral Nerves
Secondary: Acquisition & Reconstruction - Quantitative Imaging: relaxometry, multi-parametric, MR Fingerprinting, and synthetic MRI
465-03-008 · Neurography, Pain, and Spine · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row F
Keywords: Biomarkers High-resolution magnetic resonance imaging Gradient echo Morphometrics Polyneuropathies
Accepted
Jesus E Fajardo1, Hasan Sawan1, Arif Musa2, Vivian B Truong1, Yang Xuan1, Sara E Benitez3, Mary L Vo3, Richard Dortch 4, Bo Hu3, Jun Li3, Yongsheng Chen 1
1Department of Neurology, Wayne State University School of Medicine, Detroit, United States of America
2Department of Radiology, Wayne State University School of Medicine, Detroit, United States of America
3Department of Neurology, Houston Methodist Research Institute, Houston, United States of America
4Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, United States of America
Presenting Author: Yongsheng Chen

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References

1. Chen, Y., E.M. Haacke, and J. Li, Peripheral nerve magnetic resonance imaging. F1000Research, 2019. 8: p. F1000 Faculty Rev-1803. doi:10.12688/f1000research.19695.1 [doi]
2. Saba, S., et al., Demyelination in hereditary sensory neuropathy type‐1C. Annals of Clinical and Translational Neurology, 2020. 7(9): p. 1502-1512. https://doi.org/10.1002/acn3.51110 [doi]
3. Goedee, H., et al., High resolution sonography in the evaluation of the peripheral nervous system in polyneuropathy–a review of the literature. European journal of neurology, 2013. 20(10): p. 1342-1351. https://doi.org/10.1111/ene.12182 [doi]
4. Jayaprakash, N., et al., Organ-and Function-Specific Anatomical Organization of the Vagus Nerve Supports Fascicular Vagus Nerve Stimulation. Available at SSRN 4281937. https://doi.org/10.1101/2022.03.07.483266 [doi]
5. Reutskiy, S., E. Rossoni, and B. Tirozzi, Conduction in bundles of demyelinated nerve fibers: computer simulation. Biological cybernetics, 2003. 89(6): p. 439-448. https://doi.org/10.1007/s00422-003-0430-x [doi]
6. Pušnik, L., et al., Fascicle differentiation of upper extremity nerves on high-resolution ultrasound with multimodal microscopic verification. Scientific Reports, 2025. 15(1): p. 557. https://doi.org/10.1038/s41598-024-84396-y [doi]
7. Pušnik, L., et al., 3D fascicular reconstruction of median and ulnar nerve: Initial experience and comparison between high-resolution ultrasound and MR microscopy. European Radiology Experimental, 2024. 8(1): p. 100. https://doi.org/10.1186/s41747-024-00495-5 [doi]
8. Chen, Y., et al., Multiparametric quantitative MRI of peripheral nerves to differentiate axonal from demyelinating neuropathies (P11-8.002). Neurology, 2023. 100(17_supplement_2): p. 2196. https://doi.org/10.1212/WNL.0000000000202382 [doi]
9. Fridman, V., et al., Disease progression in charcot–marie–tooth disease related to MPZ mutations: A longitudinal study. Annals of neurology, 2023. 93(3): p. 563-576. https://doi.org/10.1002/ana.26518 [doi]
10. Bai, Y., et al., Conduction block in PMP22 deficiency. Journal of Neuroscience, 2010. 30(2): p. 600-608. https://doi.org/10.1523/JNEUROSCI.4264-09.2010 [doi]
11. Murphy, S.M., et al., Reliability of the CMT neuropathy score (second version) in Charcot‐Marie‐Tooth disease. Journal of the Peripheral Nervous System, 2011. 16(3): p. 191-198. https://doi.org/10.1111/j.1529-8027.2011.00350.x [doi]
12. Chen, Y., et al., Multiparametric quantitative MRI of peripheral nerves in the leg: A reliability study. Journal of Magnetic Resonance Imaging, 2024. 59(2): p. 563-574. https://doi.org/10.1002/jmri.28778 [doi]
13. Zwanenburg A, L.S., MIRP: A Python package for standardised radiomics. J Open Source Softw., 2024. 9: p. 6413. doi:10.21105/joss.06413 [doi]
14. Ugrenović, S., et al., Morphological and morphometric analysis of fascicular structure of tibial and common peroneal nerves. Facta Universitatis, Series: Medicine and Biology, 2014. 16(1).

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http://echo.ismrm.org/p/ISMRM2026/465-03-008