Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
606-03-003 ISMRM Abstract

Ultra-Low-Field NMR Relaxometry Reveals Anti-Invasive Effects of Bumetanide in Glioblastoma mouse model.

Primary: Contrast Mechanisms - Relaxometry
Secondary: Preclinical Animal & in vitro MR - Biomarkers
606-03-003 · Low Field MRI Applications · Thursday, 14 May, 4:00 PM–5:50 PM · Auditorium 2
Keywords: Glioblastoma Treatment monitoring Preclinical Animal Models FFC-NMR relaxometry Bumetanide
Accepted
Simona Baroni1, Sahar Rakhshan1, Michèle El-Atifi2, Ayda Zarechian Soudani1, Lionel M Broche 3, Francois Berger2,4, Simonetta Geninatti Crich1, Hana Lahrech2,3,5
1Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy
2BrainTech Lab INSERM U1205 and University of Grenoble Alpes France, France
3University of Aberdeen, Aberdeen, United Kingdom
4Grenoble Hospital University (CHU) France, France
5Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom
Presenting Author: Lionel M Broche

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References

1. 1. Petit M, Leclercq M, Pierre S, et al. (2022) Fast-field-cycling NMR at very low magnetic fields: water molecular dynamic biomarkers of glioma cell invasion and migration. NMR Biomed. 35. doi:10.1002/nbm.4677 [doi]
2. 2. Ruggiero MR, Ait Itto H, Baroni S, et al. (2022) Role of Transmembrane Water Exchange in Glioma Invasion/Migration: In Vivo Preclinical Study by Relaxometry at Very Low Magnetic Field. Cancers: 14, 4180. doi:10.3390/cancers14174180 [doi]
3. 3. El-Atifi M, Berger F, Lahrech H (2024) Bumetanide drug effect on the transmembrane water exchange by T1 relaxation at ultra-low field. In proceeding of the ISMRM annual meeting, Singapore, p 7284.
4. 4. Luo L, Guan X, Begum G, et al. (2020) Blockade of Cell Volume Regulatory Protein NKCC1 Increases TMZ-Induced Glioma Apoptosis and Reduces Astrogliosis. Mol Cancer Ther 9: 1550–1561. doi:10.1158/1535-7163.MCT-19-0910 [doi]
5. 5. Migliati E, Meurice N, Du Bois P, et al. (2009) Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site. Mol Pharmacol 76:105–12. doi:10.1124/mol.108.053744 [doi]
6. 6. Zhu W, Begum G, Pointer K, et al. (2014) WNK1-OSR1 kinase-mediated phospho-activation of Na⁺-K⁺-2Cl⁻ cotransporter facilitates glioma migration. Mol Cancer 13:1–15. doi:10.1186/1476-4598-13-31 [doi]
7. 7. Mallikourti V, Ross PJ, Maier O. et al. (2024) Field cycling imaging to characterise breast cancer at low and ultra-low magnetic fields below 0.2 T. Commun Med 4: 221. doi:10.1038/s43856-024-00644-2 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/606-03-003