Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
664-02-014 ISMRM Abstract

Characterizing the effects of novel, formaldehyde-free fixation method on the human brain with in situ relaxometry

Primary: Contrast Mechanisms - Relaxometry
Secondary: Preclinical Animal & in vitro MR - Biology, Models, Methods
664-02-014 · Large Animals · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row E
Keywords: Brain Relaxometry Fixation Post-mortem
Accepted
David Leonard E Asuncion1, Kayla Gray2,3, Hahn Soe-Lin3,4,5,6, Chris Blais7, Marco Santello1, Rosalind J Sadleir1
1School of Biological and Health Systems Engineering, Arizona State University, Tempe, United States of America
2Edson College of Nursing and Healthcare Innovation, Arizona State University, Tempe, United States of America
3St. Joseph's Hospital and Medical Center, CommonSpirit Health, Phoenix, United States of America
4Department of Surgery, Creighton University School of Medicine - Phoenix Regional Campus, Phoenix, United States of America
5Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, United States of America
6Department of Surgery, University of Arizona School of Medicine, Tucson, United States of America
7Department of Psychology, Arizona State University, Tempe, United States of America
Presenting Author: Yuxiang Zhou

Synopsis

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References

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2. Shepherd TM, Flint JJ, Thelwall PE, Stanisz GJ, Mareci TH, Yachnis AT, et al. Postmortem interval alters the water relaxation and diffusion properties of rat nervous tissue — Implications for MRI studies of human autopsy samples. NeuroImage. 2009 Feb;44(3):820–6. doi:10.1016/j.neuroimage.2008.09.054 [doi]
3. Shatil AS, Uddin MN, Matsuda KM, Figley CR. Quantitative Ex Vivo MRI Changes due to Progressive Formalin Fixation in Whole Human Brain Specimens: Longitudinal Characterization of Diffusion, Relaxometry, and Myelin Water Fraction Measurements at 3T. Frontiers in Medicine. 2018 Feb 20;5. doi:10.3389/fmed.2018.00031 [doi]
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10. Jenkinson M, Bannister P, Brady M, Smith S. Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images. NeuroImage. 2002 Oct;17(2):825–41. doi:10.1006/nimg.2002.1132 [doi]
11. Yushkevich PA, Piven J, Hazlett HC, Smith RG, Ho S, Gee JC, et al. User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability. NeuroImage. 2006 Jul;31(3):1116–28. doi:10.1016/j.neuroimage.2006.01.015 [doi]
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Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/664-02-014