Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
668-01-002 ISMRM Abstract

Novel Iron(III)-based MR imaging marker for the early detection of abdominal aortic aneurysms

Primary: Cardiovascular - Vascular and Vessel Wall
Secondary: Contrast Mechanisms - Molecular Imaging
668-01-002 · Molecular Imaging and Ultra High Field Acquisition · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row I
Keywords: Contrast Agents Abdominal aortic aneurysm Gadolinium-Free
Accepted
Felix Reuter 1, Lorenzo Palagi2, Sergio Padovan2, Avan Kader1, Eliana Gianolio2, Giuseppe Digilio2, Silvio Aime2, Marcus R Makowski1
1Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany
2Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy
Presenting Author: Felix Reuter

Synopsis

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References

1. Abdominal aortic aneurysms. Nat Rev Dis Primers 2018; 4: 35. doi: 10.1038/s41572-018-0036-1 [doi]
2. Bossone, E., Eagle, K.A. Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes. Nat Rev Cardiol 2021; 18: 331-348. doi: 10.1038/s41569-020-00472-6 [doi]
3. Weiss, N. et al. Medical management of abdominal aortic aneurysms. Vasa 2014; 43: 415-421. doi: 10.1024/0301-1526/a000388 [doi]
4. Wanhainen, A. et al. European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-Iliac Artery Aneurysms. Eur J Endovasc Surg 2024; 67(2): 192-331. doi: 10.1016/j.ejvs.2023.11.002 [doi]
5. Sakalihasan, N. et al. Abdominal aortic aneurysm. The Lancet. 2005; 9470: 1577-1589. doi: 10.1016/S0140-6736(05)66459-8 [doi]
6. Suna, G. et al. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries. Circulation 2018; 137: 166-183. doi: 10.1161/CIRCULATIONAHA.116.023381 [doi]
7. Ren, P., Hughes, M., Krishnamoorthy, S. et al. Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. Sci Rep 2017; 7: 12351. doi: 10.1038/s41598-017-12248-z [doi]
8. Kaufmann, J. O., Brangsch, J., Kader, A. et al. ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries. Nat Commun 2022; 13: 2867. doi: 10.1038/s41467-022-30464-8 [doi]
9. Fretellier, N. Gadolinium Deposition in Bone Tissues After Contrast-enhanced Magnetic Resonance Imaging. Invest Radiol 2025; 60(11): 722-744. doi: 10.1097/RLI.0000000000001208 [doi]
10. Rogosnitzky, M., Branch, S. Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms. Biometals 2016; 29: 365-376. doi: 10.1007/s10534-016-9931-7 [doi]
11. McDonald, R. J. et al. Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging. Radiology 2015; 275(3): 772-782. doi: 10.1148/radiol.15150025 [doi]
12. Palagi, L. et al. Fe(deferasirox)2: An Iron(III)-Based Magnetic Resonance Imaging T1 Contrast Agent Endowed with Remarkable Molecular and Functional Characteristics. J. Am. Chem. Soc. 2021; 143(35): 14178-14188. doi: 10.1021/jacs.1c04963 [doi]

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http://echo.ismrm.org/p/ISMRM2026/668-01-002