Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
561-05-010 Registered Abstract

Characterizing Placental Perfusion in Healthy Pregnancy and Fetal Growth Restriction with 3T IVIM and Velocity-Selective ASL

Primary: Body - Placenta
Secondary: Body - Fetal
561-05-010 · Advanced MR Techniques in Cervical, Genital, Placental, and Fetal Disorders · Wednesday, 13 May, 4:00 PM–4:55 PM · Digital Posters Row B
Keywords: Placenta IVIM-DWI Velocity-selective arterial spin labeling Fetal Growth Restriction Histopathology
Accepted
Sydney N Williams 1, Angel Torrado-Carvajal1, Laura Nuñez Gonzalez2, Pablo Garcia-Polo2, Susana Borromeo1,3, Rita Regojo4, Olga Nieto Velasco5,6, luis Hernandez-Garcia7, Manuel Recio-Rodríguez6,8
1Medical Image Analysis and Biometry Lab, Universidad Rey Juan Carlos, Móstoles, Spain
2GE HealthCare, Madrid, Spain
3Bioengineering Systems and Technologies Research Group, Universidad Rey Juan Carlos, Móstoles, Spain
4Anatomical Pathology Department, Hospital Universitario Quirónsalud, Madrid, Spain
5Department of Gynecology and Obstetrics, Hospital Universitario Quirónsalud, Madrid, Spain
6Faculty of Medicine, Health and Sports, Universidad Europea, Madrid, Spain
7Department of Radiology, University of Michigan, Ann Arbor, United States of America
8Radiology Department, Hospital Universitario Quirónsalud, Madrid, Spain
Presenting Author: Sydney N Williams

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References

1. Gordijn, SJ, et al., “Consensus definition of fetal growth restriction: a Delphi procedure,” Ultrasound Obstet Gynecol, 2016, 48: 333-339. https://doi.org/10.1002/uog.15884. [doi]
2. Miller, SL, Huppi, PS, and Mallard, C, “The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome.” J Physiol, 2016, 594: 807-823. https://doi.org/10.1113/JP271402. [doi]
3. Villalaín, C, et al., “Clinical practice guidance for the management of fetal growth restriction: an expert review,” The Journal of Maternal-Fetal & Neonatal Medicine, 2025, 38(1). https://doi.org/10.1080/14767058.2025.2526111 [doi]
4. Andescavage, N, et al., “Exploring in vivo placental microstructure in healthy and growth-restricted pregnancies through diffusion-weighted magnetic resonance imaging,” Placenta, 2020, 93:113-118. https://doi.org/10.1016/j.placenta.2020.03.004 [doi]
5. Zun, Z, Limperopoulos, C. “Placental perfusion imaging using velocity-selective arterial spin labeling,” Magn Reson Med., 2018, 80(3):1036-1047. https://doi.org/10.1002/mrm.27100 [doi]
6. Seiter, D, et al., “Velocity-selective arterial spin labeling perfusion measurements in 2nd trimester human placenta with varying BMI,” Placenta, 2024, 150:72-79. https://doi.org/10.1016/j.placenta.2024.03.012 [doi]
7. Harteveld, AA, et al., “Systematic evaluation of velocity-selective arterial spin labeling settings for placental perfusion measurement,” Magn Reson Med, 2020, 84:1828–1843. https://doi.org/10.1002/mrm.28240 [doi]
8. Sadiku, E, et al. "Advanced magnetic resonance imaging in human placenta: insights into fetal growth restriction and congenital heart disease," Frontiers in Cardiovascular Medicine, 2024, 11:1426593. https://doi.org/10.3389/fcvm.2024.1426593 [doi]
9. Hernandez-Garcia, L, Frey, D, Nielsen, J-F, and Noll, DC, “Blood volume based functional MRI using velocity selective pulses and SERIOS readout,” Proc. Int. Soc. Magn. Reason. Med., 2023. Toronto, Canada, p. 0920.
10. Schmithorst, VJ, et al., “Optimized simultaneous ASL and BOLD functional imaging of the whole brain,” J. Magn. Reson. Imaging, 2014, 39: 1104-1117. https://doi.org/10.1002/jmri.24273. [doi]
11. Luo, J, et al., “In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study,” Sci. Rep., 2017, 7: 3713. https://doi.org/10.1038/s41598-017-03450-0 [doi]
12. Walsh, CJ et al., "Quantitative evaluation of placental microvascular blood flow and microstructure in fetal growth restriction with IVIM MRI", Pediatr. Radiol., 2025, 55(3):546-555. https://link.springer.com/article/10.1007/s00247-024-06151-9
13. Chang, YV, Vidorreta, M, Wang, Z, and Detre, JA, "3D-accelerated, stack-of-spirals acquisitions and reconstruction of arterial spin labeling MRI,", Magn. Reson. Med., 2017, 78(4):1405-1419. https://doi.org/10.1002/mrm.26549 [doi]
14. Schick, F, "Whole-body MRI at high field: technical limits and clinical potential,", Eur. Radiol., 2005, 15(5):946-59.://link.springer.com/article/10.1007/s00330-005-2678-0.

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http://echo.ismrm.org/p/ISMRM2026/561-05-010