Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
668-02-002 ISMRM Abstract

Brain GABA and glutathione in people living with HIV

Primary: Neuro - Infectious Disease
Secondary: Neuro - Aging
668-02-002 · Spectroscopy and Spectroscopic Imaging: Applications · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row I
Keywords: In vivo proton magnetic resonance spectroscopy Gamma-aminobutyric acid Glutathione HIV Smokers
Accepted
Muhammad G Saleh 1,2, Reza Abdavies1, Lisa Blaskey1,2, Luke Bloy1,2, Funmi Aka-Bashorun1, Saipavitra Murali-Manohar3, Timothy P Roberts1,2, Elizabeth Lowenthal1, Robert Gross2, William R Short2
1Children's Hospital of Philadelphia, Philadelphia, United States of America
2University of Pennsylvania, Philadelphia, United States of America
3Johns Hopkins University School of Medicine, Baltimore, United States of America
Presenting Author: Muhammad G Saleh

Synopsis

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References

1. Woods SP, Moore DJ, Weber E, Grant I. Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychology review. 2009;19(2):152-68.
2. Mdodo R, Frazier EL, Dube SR, Mattson CL, Sutton MY, Brooks JT, Skarbinski J. Cigarette smoking prevalence among adults with HIV compared with the general adult population in the United States: cross-sectional surveys. Annals of internal medicine. 2015;162(5):335-44.
3. Burden of Cigarette Use in the U.S. https://www.cdc.gov/tobacco/campaign/tips/resources/data/cigarette-smoking-in-united-states.html: U.S. Department of Health & Human Services. Last Updated May 17, 2021. Accessed November 15, 2021.
4. Current Cigarette Smoking Among Adults in the United States. https://www.cdc.gov/tobacco/data_statistics/fact_sheets/adult_data/cig_smoking/index.htm: U.S. Department of Health & Human Services. Last Updated December 10, 2020. Accessed November 15, 2021.
5. Calvo M, Laguno M, Martinez M, Martinez E. Effects of tobacco smoking on HIV-infected individuals. AIDS reviews. 2015;17(1):47-55. PMID: 25427101. [pmid]
6. Ande A, McArthur C, Ayuk L, Awasom C, Achu PN, Njinda A, Sinha N, Rao PS, Agudelo M, Nookala AR, Simon S, Kumar A, Kumar S. Effect of mild-to-moderate smoking on viral load, cytokines, oxidative stress, and cytochrome P450 enzymes in HIV-infected individuals. PLoS One. 2015;10(4):e0122402; PMCID: PMC4399877.
7. Buzhdygan T, Lisinicchia J, Patel V, Johnson K, Neugebauer V, Paessler S, Jennings K, Gelman B. Neuropsychological, neurovirological and neuroimmune aspects of abnormal GABAergic transmission in HIV infection. Journal of NeuroImmune Pharmacology. 2016;11(2):279-93.
8. Zhang J, Du EE-J, Watson RR. Side-stream cigarette smoke accentuates immunomodulation during murine AIDS. International immunopharmacology. 2002;2(6):759-66.
9. Royal W, Can A, Gould TD, Guo M, Huse J, Jackson M, Davis H, Bryant J. Cigarette smoke and nicotine effects on brain proinflammatory responses and behavioral and motor function in HIV-1 transgenic rats. Journal of neurovirology. 2018;24(2):246-53.
10. Saleh MG, Oeltzschner G, Chan KL, Puts NA, Mikkelsen M, Schär M, Harris AD, Edden RA. Simultaneous edited MRS of GABA and glutathione. NeuroImage. 2016;15:576-82; PMCID: PMC5159266.
11. Oeltzschner G, Zöllner HJ, Hui SC, Mikkelsen M, Saleh MG, Tapper S, Edden RA. Osprey: Open-Source Processing, Reconstruction & Estimation of Magnetic Resonance Spectroscopy Data. Journal of Neuroscience Methods. 2020;343; PMCID: PMC7477913.
12. Provencher SW. Automatic quantitation of localized in vivo1H spectra with LCModel. NMR in Biomedicine. 2001;14(4):260-4.
13. Gasparovic C, Song T, Devier D, Bockholt HJ, Caprihan A, Mullins PG, Posse S, Jung RE, Morrison LA. Use of tissue water as a concentration reference for proton spectroscopic imaging. Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine. 2006;55(6):1219-26.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/668-02-002