Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-01-016 / 552-01-016 ISMRM Abstract

In vivo 2H-MRI Detection of AAV-Mediated Liver Gene Delivery Using the Human Thymidine Kinase-1 Reporter Gene

Primary: Preclinical Animal & in vitro MR - Probes & Targets
Secondary: Contrast Mechanisms - Deuterium
552-01-016 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
552-01-016 · Novel Approaches to Spectroscopy · Wednesday, 13 May, 8:20 AM–9:56 AM · Power Pitch Theatre 2
Keywords: Cell Tracking & Reporter Genes Deuterium Metabolic Imaging Preclinical Animal Models Liver MRI Gene delivery
Accepted
Hyla Allouche-Arnon 1, Oded Singer2, Elton T Montrazi3, Talia Harris4, Amnon Bar-Shir1
1Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot, Israel
2Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel
3Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel
4Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel
Presenting Author: Hyla Allouche-Arnon

Synopsis

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References

1. Wang, JH., Gessler, D.J., Zhan, W. et al. Adeno-associated virus as a delivery vector for gene therapy of human diseases. Sig Transduct Target Ther 9, 78 (2024). https://doi.org/10.1038/s41392-024-01780-w [doi]
2. Morath, V., Fritschle, K., Warmuth, L. et al. PET-based tracking of CAR T cells and viral gene transfer using a cell surface reporter that binds to lanthanide complexes. Nat. Biomed. Eng (2025). https://doi.org/10.1038/s41551-025-01415-7 [doi]
3. H. Allouche-Arnon, E. T. Montrazi, B. Subramani, M. Fisler, I. Spigel, L. Frydman, et al. J. Am. Chem. Soc. (2024) 146, 46 DOI: 10.1021/jacs.4c09572 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/552-01-016