Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
366-05-005 ISMRM Abstract

Comparison of Breath-Hold and Free-Breathing MRI Methods for Liver PDFF and R2* Quantification in an Elderly Cohort

Primary: Body - Liver
Secondary: Acquisition & Reconstruction - Quantitative Imaging: chest, abdomen, and pelvis
366-05-005 · Quantitative Applications in Body MRI: Make the Numbers Count · Monday, 11 May, 4:10 PM–5:05 PM · Digital Posters Row G
Keywords: Liver Proton density fat fraction (PDFF) Radial MRI MASLD R2star mapping
Accepted
Krystalyn K Edwards-Calma1, Zackary Kon2, Zidan Yu3, Nhat Dainelle Vallo1, Megan Buras2, Kai Tobias Block4,5,6, Unhee Lim7, Christoph A Rettenmeier1
1Medicine, University of Hawaii, Honolulu, United States of America
2University of Hawaii, Honolulu, United States of America
3Philips, Best, Netherlands
4NYU School of Medicine, New York, United States of America
5Department of Radiology, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, United States of America
6Department of Radiology, Center for Advanced Imaging Innovation and Research (CAI²R), New York University Grossman School of Medicine, New York, United States of America
7University of Hawaii Cancer Center, University of Hawaii, Honolulu, United States of America
Presenting Author: Benedikt A Poser

Synopsis

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References

1. Powell EE, Wong VW, Rinella M. Non-alcoholic fatty liver disease. Lancet 2021;397(10290):2212-2224.
2. Eslam M, Newsome PN, Sarin SK, Anstee QM, Targher G, Romero-Gomez M, Zelber-Sagi S, Wai-Sun Wong V, Dufour JF, Schattenberg JM, Kawaguchi T, Arrese M, Valenti L, Shiha G, Tiribelli C, Yki-Jarvinen H, Fan JG, Gronbaek H, Yilmaz Y, Cortez-Pinto H, Oliveira CP, Bedossa P, Adams LA, Zheng MH, Fouad Y, Chan WK, Mendez-Sanchez N, Ahn SH, Castera L, Bugianesi E, Ratziu V, George J. A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement. J Hepatol 2020;73(1):202-209.
3. Chan W-K, Chuah K-H, Rajaram RB, Lim L-L, Ratnasingam J, Vethakkan SR. Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review. JOMES 2023;32(3):197-213.
4. Castera L, Friedrich-Rust M, Loomba R. Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology 2019;156(5):1264-1281 e1264.
5. Caussy C, Reeder SB, Sirlin CB, Loomba R. Noninvasive, Quantitative Assessment of Liver Fat by MRI-PDFF as an Endpoint in NASH Trials. Hepatology 2018;68(2):763-772.
6. Schneider M, Benkert T, Solomon E, Nickel D, Fenchel M, Kiefer B, Maier A, Chandarana H, Block KT. Free-breathing fat and R2* quantification in the liver using a stack-of-stars multi-echo acquisition with respiratory-resolved model-based reconstruction. Magnetic Resonance in Medicine 2020;84(5):2592-2605.
7. Benkert T, Feng L, Sodickson DK, Chandarana H, Block KT. Free-breathing volumetric fat/water separation by combining radial sampling, compressed sensing, and parallel imaging. Magnetic Resonance in Medicine 2017;78(2):565-576.
8. Zhong X, Nickel MD, Kannengiesser SA, Dale BM, Kiefer B, Bashir MR. Liver fat quantification using a multi-step adaptive fitting approach with multi-echo GRE imaging. Magn Reson Med 2014;72(5):1353-1365.
9. Campo CA, Hernando D, Schubert T, Bookwalter CA, Pay AJV, Reeder SB. Standardized Approach for ROI-Based Measurements of Proton Density Fat Fraction and R2* in the Liver. AJR Am J Roentgenol 2017;209(3):592-603.
10. Henninger B, Zoller H, Kannengiesser S, Zhong X, Jaschke W, Kremser C. 3D Multiecho Dixon for the Evaluation of Hepatic Iron and Fat in a Clinical Setting. Journal of Magnetic Resonance Imaging 2017;46(3):793-800.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/366-05-005