Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
552-03-016 / 552-03-016 ISMRM Abstract

Reproducibility, reliability, and harmonisation of fixel-based analysis (a travelling heads study)

Primary: Diffusion - Diffusion Analysis & Visualization
Secondary: Neuro - White Matter
552-03-016 · Diffusion Methodologies and Clinical Applications · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 2
552-03-016 · Diffusion Methodologies and Clinical Applications · Wednesday, 13 May, 4:00 PM–5:36 PM · Power Pitch Theatre 2
Keywords: Diffusion Analysis and Visualization Fixel-based analysis Diffusion MRI Harmonisation Reproducibility
Accepted
Remika Mito 1,2, Sila Genc3,4, Michael Mercieca1, Joseph Y Yang4,5, Robert Smith2,6, Andrew Zalesky7,8
1Department of Psychiatry, University of Melbourne, Melbourne, Australia
2Florey Department of Neuroscience and Mental Health, Melbourne, Australia
3Developmental Imaging, Murdoch Children’s Research Institute, Melbourne, Australia, Australia
4Department of Neurosurgery, Royal Childrens Hospital, Melbourne, Australia
5Department of Paediatrics, University of Melbourne, Melbourne, Australia
6Florey Institute of Neuroscience and Mental Health, Melbourne, Australia
7Departments of Psychiatry and Biomedical Engineering, University of Melbourne, Melbourne, Australia
8Department of Biomedical Engineering, University of Melbourne, Melbourne, Australia
Presenting Author: Remika Mito

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Raffelt, D. A. et al. Investigating white matter fibre density and morphology using fixel-based analysis. NeuroImage 144, 58–73 (2017).
2. Fortin, J.-P. et al. Harmonization of multi-site diffusion tensor imaging data. NeuroImage 161, 149–170 (2017).
3. Hutter, J. et al. Time-efficient and flexible design of optimized multishell HARDI diffusion. Magnetic Resonance in Medicine 79, 1276–1292 (2018).
4. Tournier, J.-D. et al. A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging. NMR Biomed. 33, e4348 (2020).
5. Tournier, J.-D. et al. MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation. Neuroimage 202, 116137 (2019).
6. Veraart, J. et al. Denoising of diffusion MRI using random matrix theory. NeuroImage 142, 394–406 (2016).
7. Kellner, E., Dhital, B., Kiselev, V. G. & Reisert, M. Gibbs-ringing artifact removal based on local subvoxel-shifts. Magn. Reson. Med. 76, 1574–1581 (2016).
8. Andersson, J. L. R., Skare, S. & Ashburner, J. How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging. NeuroImage 20, 870–888 (2003).
9. Andersson, J. L. R. & Sotiropoulos, S. N. An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. NeuroImage 125, 1063–1078 (2016).
10. Bastiani, M. et al. Automated quality control for within and between studies diffusion MRI data using a non-parametric framework for movement and distortion correction. NeuroImage 184, 801–812 (2019).
11. Tustison, N. J. et al. N4ITK: Improved N3 Bias Correction. IEEE Trans. Med. Imaging 29, 1310–1320 (2010).
12. Jeurissen, B., Tournier, J.-D., Dhollander, T., Connelly, A. & Sijbers, J. Multi-tissue constrained spherical deconvolution for improved analysis of multi-shell diffusion MRI data. NeuroImage 103, 411–426 (2014).
13. Mito, R. et al. ComBat scanner harmonization for fixel-based analysis. in Proc Int Soc Mag Res Med 3243 (Toronto, Canada, 2023).
14. Wasserthal, J., Neher, P. & Maier-Hein, K. H. TractSeg-Fast and accurate white matter tract segmentation. NeuroImage 183, 239–253 (2018).
15. Koller, K. et al. MICRA: Microstructural image compilation with repeated acquisitions. NeuroImage 225, 117406 (2021).
16. Vollmar, C. et al. Identical, but not the same: Intra-site and inter-site reproducibility of fractional anisotropy measures on two 3.0 T scanners. NeuroImage 51, 1384–1394 (2010).
17. Richter, S. et al. Validation of cross-sectional and longitudinal ComBat harmonization methods for magnetic resonance imaging data on a travelling subject cohort. Neuroimage Rep. 2, 100136 (2022).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/552-03-016