Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
362-03-007 ISMRM Abstract

Thalamic Microstructural Deficits in Young Adults with Autism Spectrum Disorder

Primary: Neuro - Psychiatric Disorders
Secondary: Diffusion - Microstructure
362-03-007 · Neuroimaging Signatures Across the Psychiatric Spectrum · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row C
Keywords: Microstructure Brain Development Autism spectrum disorder Diffusion kurtosis imaging Thalamus
Accepted
Beatrice Lattanzi1, Faye F McKenna 1, Mariana Lazar1
1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, New York, United States of America
Presenting Author: Faye F McKenna

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References

1. Schuetze, M. et al. Morphological Alterations in the Thalamus, Striatum, and Pallidum in Autism Spectrum Disorder. Neuropsychopharmacology 41, 2627-2637 (2016). https://doi.org/10.1038/npp.2016.64 [doi]
2. Ayub, R. et al. Thalamocortical connectivity is associated with autism symptoms in high-functioning adults with autism and typically developing adults. Transl Psychiatry 11, 93 (2021). https://doi.org/10.1038/s41398-021-01221-0 [doi]
3. McLaughlin, K. et al. Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder. Autism Res 11, 450-462 (2018). https://doi.org/10.1002/aur.1909 [doi]
4. Jensen, J. H., Helpern, J. A., Ramani, A., Lu, H. & Kaczynski, K. Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med 53, 1432-1440 (2005). https://doi.org/10.1002/mrm.20508 [doi]
5. Helpern, J. A. et al. Preliminary evidence of altered gray and white matter microstructural development in the frontal lobe of adolescents with attention-deficit hyperactivity disorder: a diffusional kurtosis imaging study. J Magn Reson Imaging 33, 17-23 (2011). https://doi.org/10.1002/jmri.22397 [doi]
6. Bester, M. et al. Non-Gaussian diffusion MRI of gray matter is associated with cognitive impairment in multiple sclerosis. Mult Scler 21, 935-944 (2015). https://doi.org/10.1177/1352458514556295 [doi]
7. McKenna, F. F., Miles, L., Babb, J. S., Goff, D. C. & Lazar, M. Diffusion kurtosis imaging of gray matter in schizophrenia. Cortex 121, 201-224 (2019). https://doi.org/10.1016/j.cortex.2019.08.013 [doi]
8. Horata, E., Ay, H. & Aslan, D. Autistic-like behaviour and changes in thalamic cell numbers a rat model of valproic acid-induced autism; A behavioural and stereological study. Brain Res 1840, 149047 (2024). https://doi.org/10.1016/j.brainres.2024.149047 [doi]

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http://echo.ismrm.org/p/ISMRM2026/362-03-007