Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
363-02-003 ISMRM Abstract

Structural Changes in Gray Matter and White Matter across the Alzheimer's disease continuum

Primary: Diffusion - Microstructure
Secondary: Neuro - Alzheimer's Disease
363-02-003 · All About Diffusion · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row D
Keywords: Alzheimer's Disease Diffusion Tensor Imaging Magnetic Resonance Imaging (MRI) 3D T1-weighted imaging
Accepted
Shuai Lin 1, jianxiu lian2, Wei Wang3
1Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2Philips Healthcare (Beijing), Beijing, China
3First Affiliated Hospital of Harbin Medcial University, China
Presenting Author: Shuai Lin

Synopsis

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References

1. Veitch DP, Weiner MW, Miller M, et al. The Alzheimer's disease neuroima-ging initiative in the era of Alzheimer's disease treatment: a review of ADNlstudies from 2021 to 2022.Alzheimers Dement 2024; 20(1):652-694.
2. Barthélemy NR, Li Y, Joseph-Mathurin N, et al. A soluble phosphorylated tausignature links tau, amyloid and the evolution of stages of dominantly in-herited Alzheimer's disease. Nat Med 2020: 26(3):398-407.
3. Jack Jr. CR, Bennett DA, Blennow K, et al. NlA-AA research framework:toward a biological definition of Alzheimer's disease. AlzheimersDement 2018:14(4):535-562.
4. SKOURAS S, TORNER J, ANDERSSON P, et al. Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation [J]. Brain, 2020, 143(3): 976-92.
5. SA B. Cerebral white and gray matter injury in newborns: new insights into pathophysiology and management [J]. Clin Perinatol, 2014, 41(1): 1-24.
6. JACOBS HIL H T, SCHULTZ AP, SEPULCRE J, et al. Structural tract alterations predict downstream tau ccumulation in amyloid-positive older individuals [J]. Nat Neurosci, 2018, 21(3): 424-31.
7. EZZATI A, KATZ M J, LIPTON M L, et al. Hippocampal volume and cingulum bundle fractional anisotropy are independently associated with verbal memory in older adults [J]. Brain Imaging Behav, 2016, 10(3): 652-9.
8. KC Li,Xiao L, Q Zeng,et al. The influence of cerebral small vessel disease on static and dynamicfunctional network connectivity in subjects along Alzheimer's disease continuum.Brain Connectivity, 2020.
9. QZ Zeng, KC Li, MM Zhang, et al. Distinct Atrophy Pattern of Hippocampal Subfields in Patients with Progressive and Stable Mild Cognitive Impairment: a Longitudinal MRI Study. Journal of Alzheimer’s disease, 2020.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/363-02-003