Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
465-01-007 ISMRM Abstract

SABRE-Hyperpolarized [1-13C]ketoisocaproate-d2 Allows Profiling of Branched-Chain-Amino-Acid Transferase in vitro and in vivo

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)
Secondary: Contrast Mechanisms - Molecular Imaging
465-01-007 · Hyperpolarization: Novel Applications · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row F
Keywords: 13C Metabolic imaging Hyperpolarized MRI Metabolic biomarker Parahydrogen
Accepted
Stefan Petersen 1, Philipp R Groß1,2, Paul M Schmidt1, Henri de Maissin1,2, Robert Willing1,2, Adriana Sacristán-Martín3, Lisa Heß4, Sebastian Lucas5, Maxim Zaitsev1, Dominik von Elverfeldt1,2, Martin Grashei6, Franz Schilling6,7, Max von Delius3, Thomas Reinheckel2,4,8, Andreas Schmidt1,2
1University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
2German Cancer Consortium (DKTK), partner site Freiburg, a partnership between DKFZ and University Medical Center Freiburg, Freiburg, Germany
3Institute of Organic Chemistry, University of Ulm, Ulm, Germany
4Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Stefan-Meier-Str. 17, Freiburg 79104, Freiburg, Germany
5NVision Imaging Technologies GmbH, Ulm, Germany
6Department of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
7German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and TUM, Germany
8Centre for Biological Signaling Studies BIOSS, University of Freiburg, Freiburg 79104, Freiburg, Germany
Presenting Author: Stefan Petersen

Synopsis

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References

1. Adams RW, Aguilar JA, Atkinson KD, et al. Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer. Science. 2009;323(5922):1708-1711. doi:10.1126/science.1168877 [doi]
2. Petersen S, Nagel L, Groß PR, et al. In vivo molecular imaging of breast cancer metabolic heterogeneity using [1-13C]pyruvate-d3 hyperpolarized by reversible exchange with parahydrogen. Theranostics. 2025;15(9):3714-3723. doi:10.7150/thno.103272 [doi]
3. de Maissin H, Groß PR, Mohiuddin O, et al. In Vivo Metabolic Imaging of [1-13C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen**. Angew Chem Int Ed. 2023;62(36):e202306654. doi:10.1002/anie.202306654 [doi]
4. Butt SA, Søgaard LV, Magnusson PO, et al. Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging. J Cereb Blood Flow Metab. 2012;32(8):1508-1514. doi:10.1038/jcbfm.2012.34 [doi]
5. Karlsson M, Jensen PR, in ’t Zandt R, et al. Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate. Int J Cancer. 2010;127(3):729-736. doi:10.1002/ijc.25072 [doi]
6. Schmidt AB, Eills J, Dagys L, et al. Over 20% Carbon-13 Polarization of Perdeuterated Pyruvate Using Reversible Exchange with Parahydrogen and Spin-Lock Induced Crossing at 50 μT. J Phys Chem Lett. 2023;14(23):5305-5309. doi:10.1021/acs.jpclett.3c00707 [doi]
7. Christensen DB, Skre IS, Ardenkjær-Larsen JH, Karlsson M, Lerche MH. Developing hyperpolarized metabolic contrast agents at high field dDNP for large animal research. J Magn Reson Open. 2025;22:100184. doi:10.1016/j.jmro.2024.100184 [doi]
8. Billingsley KL, Park JM, Josan S, et al. The feasibility of assessing branched-chain amino acid metabolism in cellular models of prostate cancer with hyperpolarized [1-13C]-ketoisocaproate. Magn Reson Imaging. 2014;32(7):791-795. doi:10.1016/j.mri.2014.04.015 [doi]
9. Theis T, Truong M, Coffey AM, Chekmenev EY, Warren WS. LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization. J Magn Reson. 2014;248:23-26. doi:10.1016/j.jmr.2014.09.005 [doi]
10. Adelabu I, Chowdhury MRH, Nantogma S, et al. Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-13C]ketoisocaproate. Metabolites. 2023;13(2):200. doi:10.3390/metabo13020200 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/465-01-007