Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
465-01-006 ISMRM Abstract

Pharmacokinetic Modeling with a Convolutional Neural Network of Hyperpolarized 13C-Pyruvate MRI Metabolism in the Human Heart

Primary: Analysis Methods - Classification and Prediction
Secondary: Physics & Engineering - Phantoms
465-01-006 · Hyperpolarization: Novel Applications · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row F
Keywords: Hyperpolarized 13C MRI Cardiovascular disease CNN Digital phantom
Accepted
Mario E Quicana1,2, Anna C Bennett Haller3,4, Dillon Yeh, Sule Sahin, Nikhil Deveshwar5, Avantika Sinha 3,4, Peder Larson3
1University of California at Berkeley, berkeley, United States of America
2UCSF-Radiology, United States of America
3Department of Radiology and Biomedical Imaging, University Of California, San Francisco (UCSF), United States of America
4UCSF-UC Berkeley Graduate Program in Bioengineering, United States of America
5University of California San Francisco, San Francisco, United States of America
Presenting Author: Avantika Sinha

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References

1. Cunningham CH, Lau JYC, Chen AP, et al. Hyperpolarized 13C Metabolic MRI of the Human HeartNovelty and Significance: Initial Experience. Circ Res. 2016;119(11):1177-1182. doi:10.1161/CIRCRESAHA.116.309769 [doi]
2. Larson PEZ, Tang S, Liu X, et al. Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge. J Cardiovasc Magn Reson. 2023;25:77. doi:10.1186/s12968-023-00972-7 [doi]
3. Joergensen SH, Hansen ESS, Bøgh N, et al. Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging. J Cardiovasc Magn Reson. 2022;24(1):34. doi:10.1186/s12968-022-00860-6 [doi]
4. Park JM, Reed GD, Liticker J, et al. Effect of Doxorubicin on Myocardial Bicarbonate Production From Pyruvate Dehydrogenase in Women With Breast Cancer. Circ Res. 2020;127(12):1568-1570. doi:10.1161/CIRCRESAHA.120.317970 [doi]
5. Rider OJ, Apps A, Miller JJJJ, et al. Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized 13C MRI. Circ Res. 2020;126(6):725-736. doi:10.1161/CIRCRESAHA.119.316260 [doi]
6. Joergensen SH, Hansen ESS, Bøgh N, et al. Hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging identifies metabolic phenotypes in patients with heart failure. J Cardiovasc Magn Reson. 2024;26(2):101095. doi:10.1016/j.jocmr.2024.101095 [doi]
7. Apps A, Lau JYC, Miller JJJJ, et al. Proof-of-Principle Demonstration of Direct Metabolic Imaging Following Myocardial Infarction Using Hyperpolarized 13C CMR. JACC Cardiovasc Imaging. 2021;14(6):1285-1288. doi:10.1016/j.jcmg.2020.12.023 [doi]
8. Sahin, S., Haller, A. B., Gordon, J., Kim, Y., Hu, J., Nickles, T., ... & Larson, P. E. (2025). Spatially constrained hyperpolarized 13C MRI pharmacokinetic rate constant map estimation using a digital brain phantom and a U-Net. Journal of Magnetic Resonance, 371, 107832. https://doi.org/10.1016/j.jmr.2025.107832 [doi]
9. Fonseca CG, Backhaus M, Bluemke DA, et al. The Cardiac Atlas Project—an imaging database for computational modeling and statistical atlases of the heart. Bioinformatics. 2011;27(16):2288-2295. doi:10.1093/bioinformatics/btr360 [doi]
10. Petersen SE, Aung N, Sanghvi MM, et al. Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort. J Cardiovasc Magn Reson. 2016;19(1):18. doi:10.1186/s12968-017-0327-9 [doi]
11. Mauger C, Gilbert K, Lee AM, et al. Right ventricular shape and function: cardiovascular magnetic resonance reference morphology and biventricular risk factor morphometrics in UK Biobank. J Cardiovasc Magn Reson. 2019;21(1):41. doi:10.1186/s12968-019-0551-6 [doi]
12. Cardiac Atlas Project: Biventricular PCA Modes (UK Biobank). Accessed June 17, 2024. https://www.cardiacatlas.org/biventricular-modes/
13. Hyperpolarized-MRI-Toolbox. Available online at: https://github.com/LarsonLab/hyperpolarized-mri-toolbox https://dx.doi.org/10.5281/zenodo.1198915 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/465-01-006