Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
367-03-014 ISMRM Abstract

Longitudinal assessment of skeletal muscle membrane permeability in Becker muscular dystrophy via 31P-MRS and DT-MRI

Primary: Musculoskeletal - Muscle
Secondary: Contrast Mechanisms - Multi-Contrast
367-03-014 · Muscle Microstructure and Deformation · Monday, 11 May, 1:50 PM–2:45 PM · Digital Posters Row H
Keywords: Random Permeable Barrier Model Phosphorous Magnetic Resonance Spectroscopy Membrane permeability Becker muscular dystrophy Magnesium
Accepted
Esther J Schrama1, Melissa Hooijmans2, Nienke M van de Velde1, Erik H Niks1, Hermien E Kan3, Donnie Cameron 4
1Department of Neurology, Leiden University Medical Center, Leiden, Netherlands
2Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
3C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands
4Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands
Presenting Author: Donnie Cameron

Synopsis

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References

1. P. G. Carlier, B. Marty, O. Scheidegger, et al., “Skeletal Muscle Quantitative Nuclear Magnetic Resonance Imaging and Spectroscopy as an Outcome Measure for Clinical Trials,” Journal of Clinical Neuromuscular Disease 3, no. 1 (2016): 1–28. doi:10.3233/JND-160145 [doi]
2. E.J. Schrama, M.T. Hooijmans, N.M. van de Velde, E.H. Niks, H.E. Kan, D. Cameron, "Skeletal Muscle Membrane Permeability Markers Derived From 31P-MRS May Reflect Disease Activity in Becker Muscular Dystrophy," NMR in Biomedicine 38, no. 11 (2025):e70155. doi:10.1002/nbm.70155. [doi]
3. J. Burakiewicz, M. T. Hooijmans, A. G. Webb, J. J. G. M. Verschuuren, E. H. Niks, and H. E. Kan, “Improved Olefinic Fat Suppression in Skeletal Muscle DTI Using a Magnitude-Based Dixon Method,” Magnetic Resonance in Medicine 79, no. 1 (2018): 152–159. doi:10.1002/mrm.26655 [doi]
4. C. Wary, C. Brillault-Salvat, G. Bloch, et al., “Effect of Chronic Magnesium Supplementation on Magnesium Distribution in Healthy Volunteers Evaluated by 31P-NMRS and Ion Selective Electrodes,” British Journal of Clinical Pharmacology 48, no. 5 (1999): 655–662. doi:10.1046/j.1365-2125.1999.00063.x [doi]
5. D. Cameron, T. Abbassi-Daloii, L. G. Heezen, et al., “Diffusion-Tensor Magnetic Resonance Imaging Captures Increased Skeletal Muscle Fibre Diameters in Becker Muscular Dystrophy,” Journal of Cachexia, Sarcopenia and Muscle 14, no. 3 (2023): 1546–1557. doi:10.1002/jcsm.13242 [doi]
6. D. S. Novikov, E. Fieremans, J. H. Jensen, and J. A. Helpern, “Random Walks With Barriers,” Nature Physics 7, no. 6 (2011): 508–514. doi:10.1038/nphys1936 [doi]
7. T. T. Veeger, N. M. van de Velde, K. R. Keene, et al., “Baseline Fat Fraction is a Strong Predictor of Disease Progression in Becker Muscular Dystrophy,” NMR in Biomedicine 35, no. 7 (2022): e4691. doi:10.1002/nbm.4691 [doi]
8. J.E. Tanner, "Self diffusion of water in frog muscle," Biophysical Journal. 28, no.1 (1979):107-16. doi:10.1016/S0006-3495(79)85162-0 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/367-03-014