Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
664-02-015 ISMRM Abstract

GABA Increase Revealed during Circulatory Arrest using an Improved MEGA-SPECIAL sequence with Macromolecule Suppression

Primary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
Secondary: Preclinical Animal & in vitro MR - Large Animals, Nonhuman Primates
664-02-015 · Large Animals · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row E
Keywords: Ischemia MRS Gamma-aminobutyric acid J-difference editing Brain perfusion
Accepted
Meng Gu 1, Ralph Hurd1, Daniel M Spielman1
1Department of Radiology, Stanford Medicine, Stanford, United States of America
Presenting Author: Meng Gu

Synopsis

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References

1. Hameed, I., et al., Cerebral protection strategies in aortic arch surgery: A network meta-analysis. J Thorac Cardiovasc Surg, 2020. 159(1): p. 18-31. doi: 10.1016/j.jtcvs.2019.02.045. Epub 2019 Feb 21. [doi]
2. Kajimoto, M., et al., Selective cerebral perfusion prevents abnormalities in glutamate cycling and neuronal apoptosis in a model of infant deep hypothermic circulatory arrest and reperfusion. J Cereb Blood Flow Metab, 2016. 36(11): p. 1992-2004. doi: 10.1177/0271678X16666846. [doi]
3. Mescher M, Merkle H, Kirsch J, Garwood M, Gruetter R. Simultaneous in vivo spectral editing and water suppression. NMR Biomed. 1998; 11(6):266–72. doi: 10.1002/(sici)1099-1492(199810)11:6<266::aid-nbm530>3.0.co;2-j. [doi]
4. Gu, M., et al., GABA-Editing with Macromolecule Suppression using an Improved MEGA-SPECIAL Sequence. MRM, 2018. 79(1): 41-47. doi: 10.1002/mrm.26691. Epub 2017 Mar 31. [doi]
5. Spielman, D.M., et al., Proton magnetic resonance spectroscopy assessment of neonatal brain metabolism during cardiopulmonary bypass surgery. NMR Biomed, 2022. 35(9): p. e4752. doi: 10.1002/nbm.4752. Epub 2022 May 18. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/664-02-015