Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
651-02-009 / 651-02-009 ISMRM Abstract

High-Frequency OGSE at 28.2T in a Cortical Brain Organoid and Fiber Phantom

Primary: Diffusion - Microstructure
Secondary: Acquisition & Reconstruction - Pulse Sequence Design: Non-Neuro
651-02-009 · Diffusion Modeling To Map Tissue Microstructure · Thursday, 14 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
651-02-009 · Diffusion Modeling To Map Tissue Microstructure · Thursday, 14 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
Keywords: Microstructure OGSE diffusion imaging Brain organoids Simulation-Validation Preclinical ultra-high field MRI
Accepted
Tatiana Nikolaeva 1, Maxime Yon2, Maria Paula Del Popolo1, Chantal Tax1,3
1Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands
2Laboratoire Traitement du Signal et de l'Image (LTSI), Rennes, France
3Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom
Presenting Author: Tatiana Nikolaeva

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Xu J. Probing neural tissues at small scales: Recent progress of oscillating gradient spin echo (OGSE) neuroimaging in humans. J Neuroscience Methods. 2021; 349:109024. doi.org/10.1016/j.jneumeth.2020.109024 [doi]
2. Reynaud O, Winters K V, Hoang D M, et al. Pulsed and oscillating gradient MRI for assessment of cell size and extracellular space (POMACE) in mouse gliomas. NMR in Biomedicine.2016; 29(10):1350-63. DOI: 10.1002/nbm.3577 [doi]
3. Zhu A, Michael E S, Li H, et al. Engineering clinical translation of OGSE diffusion MRI. Magn Resonance in Medicine. 2025;94(3): 913–936. doi.org/10.1002/mrm.30510 [doi]
4. Michael E S, Hennel F, Pruessmann K P. Evaluating diffusion dispersion across an extended range of b‐values and frequencies: Exploiting gap‐filled OGSE shapes, strong gradients, and spiral readouts. Magn Resonance in Medicine. 2022;87(6):2710-2723. DOI: 10.1002/mrm.29161 [doi]
5. Portnoy S, Flint J J, Blackband S J, et al. Oscillating and pulsed gradient diffusion magnetic resonance microscopy over an extended b‐value range: Implications for the characterization of tissue microstructure. Magn Resonance in Medicine.2012; 69(4): 1131–1145
6. Tax C, Nikolaeva T, Jakobs C et al. Diffusion MRI of organoids at 28.2T with 3T/m gradient strength.2025 ISMRM & ISMRT Annual Meeting. 2025
7. Yoon SJ, Elahi LS, Pașca AM, et al. Reliability of human cortical organoid generation. Nat Methods. 2019; 16: 75–78.
8. Olesen J L, Ostergaard L, Shemesh N, Jespersen S N. Diffusion time dependence, power-law scaling, and exchange in gray matter. J Neuroimage. 2022; 251:118976
9. Rohde G K , Barnett A S, Basser P J et al. Comprehensive approach for correction of motion and distortion in diffusion-weighted MRI. Magn Resonance in Medicine. 2004; 51(1):103-14.
10. Reynaud O, Winters K V, Hoang D M et al. Surface-to-volume ratio mapping of tumor microstructure using oscillating gradient diffusion weighted imaging. Magn Resonance in Medicine. 2016; 76(1):237-47.
11. Novikov DS, Kiselev VG. Surface-to-volume ratio with oscillating gradients. J Magn Reson. 2011;210(1):141-145. doi:10.1016/j.jmr.2011.02.011 [doi]
12. Zheng J, Zhong W, Sung D et al. Revealing Diffusion Frequency-Dependence in Surface-to-Volume Ratio limit using OGSE sequence on the Connectome 2.0 Scanner, presented at the 2025 ISMRM & ISMRT Annual Meeting, Honolulu, Hawaii, USA, p. 4803. doi: 10.58530/2025/4803. [doi]
13. Sukstanskii A L, Exact analytical results for ADC with oscillating diffusion sensitizing gradients, Journal of Magnetic Resonance, Volume 234, 2013, https://doi.org/10.1016/j.jmr.2013.06.016. [doi]
14. Lemberskiy G, Baete SH, Cloos MA, et al. Validation of surface‐to‐volume ratio measurements derived from oscillating gradient spin echo on a clinical scanner using anisotropic fiber phantoms. NMR in Biomedicine. 2017; 30(5).
15. Moutal N, Maximov II, Grebenkov DS. Probing Surface-to-Volume Ratio of an Anisotropic Medium by Diffusion NMR with General Gradient Encoding. IEEE Trans Med Imaging. 2019 Nov;38(11):2507-2522. doi: 10.1109/TMI.2019.2902957. Epub 2019 Mar 5. PMID: 30843822. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/651-02-009