Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
531-02-004 / 531-02-004 ISMRM Abstract

Association of OEF, CBF and CMRO2 with Tau Deposition in Older Individuals

Primary: Neuro - Aging
Secondary: Neuro - Alzheimer's Disease
531-02-004 · Imaging Neurodegeneration in Motion: Multimodal Biomarkers for Alzheimer’s Disease and Parkinson’s Disease · Wednesday, 13 May, 1:40 PM–3:16 PM · Roof Terrace
531-02-004 · Imaging Neurodegeneration in Motion: Multimodal Biomarkers for Alzheimer’s Disease and Parkinson’s Disease · Wednesday, 13 May, 1:40 PM–3:16 PM · Roof Terrace
Keywords: Aging Alzheimer's Disease Oxygen extraction fraction Cerebral metabolic rate of oxygen Cerebral blood flow (CBF)
Accepted
Hangwei Zhuang1, Liangdong Zhou2,3,4, Xiuyuan H Wang3,5, Emily B Tanzi5, Mony J de Leon5, Yi Li3,5, Pascal Spincemaille 3,6,7, Ilhami Kovanlikaya7, Thanh D Nguyen3,7,8, Yi Wang1,3,7,9, Gloria C Chiang3,5,7
1Biomedical Engineering, Cornell University, Ithaca, United States of America
2Weill Cornell Medical College, New York, United States of America
3Department of Radiology, Weill Cornell Medicine, New York, United States of America
4Department of Radiology, Weill Cornell Medical College, New York, United States of America
5Department of Radiology, Brain Health Imaging Institute, New york, United States of America
6Weill Cornell Medicine, New York, United States of America
7Radiology, Weill Cornell Medicine, New York, United States of America
8Radiology, Weill Cornell Medical College, New York, United States of America
9Department Radiology & Biomedical Engineering, Weill Cornell Medicine, Cornell University, New York, United States of America
Presenting Author: Alexandra G Roberts

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References

1. Savola S, Kaivola K, Raunio A, et al. Primary age-related tauopathy in a Finnish population-based study of the oldest old (Vantaa 85+). Neuropathol Appl Neurobiol. Apr 2022;48(3):e12788. doi:10.1111/nan.12788 [doi]
2. Ghoshal N, Garcia-Sierra F, Wuu J, et al. Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease. Exp Neurol. Oct 2002;177(2):475-93. doi:10.1006/exnr.2002.8014 [doi]
3. Nelson PT, Alafuzoff I, Bigio EH, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol. May 2012;71(5):362-81. doi:10.1097/NEN.0b013e31825018f7 [doi]
4. Rolstad S, Berg AI, Bjerke M, Johansson B, Zetterberg H, Wallin A. Cerebrospinal fluid biomarkers mirror rate of cognitive decline. J Alzheimers Dis. 2013;34(4):949-56. doi:10.3233/JAD-121960 [doi]
5. Cho J, Spincemaille P, Nguyen TD, Gupta A, Wang Y. Temporal clustering, tissue composition, and total variation for mapping oxygen extraction fraction using QSM and quantitative BOLD. Magnetic Resonance in Medicine. Jun 10 2021;doi:10.1002/mrm.28875 [doi]
6. Liu Z, Spincemaille P, Yao Y, Zhang Y, Wang Y. MEDI+0: Morphology enabled dipole inversion with automatic uniform cerebrospinal fluid zero reference for quantitative susceptibility mapping. Magn Reson Med. May 2018;79(5):2795-2803. doi:10.1002/mrm.26946 [doi]
7. Liu J, Liu T, de Rochefort L, et al. Morphology enabled dipole inversion for quantitative susceptibility mapping using structural consistency between the magnitude image and the susceptibility map. Neuroimage. Feb 1 2012;59(3):2560-8. doi:10.1016/j.neuroimage.2011.08.082 [doi]
8. Liu T, Khalidov I, de Rochefort L, et al. A novel background field removal method for MRI using projection onto dipole fields (PDF). NMR Biomed. Nov 2011;24(9):1129-36. doi:10.1002/nbm.1670 [doi]
9. Fischl B. FreeSurfer. Neuroimage. Aug 15 2012;62(2):774-81. doi:10.1016/j.neuroimage.2012.01.021 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/531-02-004