Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-04-004 ISMRM Abstract

The Association of 5.0 Tesla MRI-based Comprehensive CSVD Burden Scoring with Glymphatic Function Impairment

Primary: Neuro - Stroke and Cerebrovascular Disorders
Secondary: Diffusion - DWI/DTI/DKI
663-04-004 · Cerebral Small Vessel Disease: Network, Glymphatic, and Blood Flow · Thursday, 14 May, 2:35 PM–3:30 PM · Digital Posters Row D
Keywords: Cerebral small vessel disease DTI-ALPS Ultra-high field (UHF) MRI Glymphatic system function Perivascular spaces (PVS)
Accepted
Tengfei Song1, Pan Wang 1, Jing Yang2, Hai Lin2, Lixin Du1
1Shenzhen Longhua District Central Hospital, Shenzhen, China
2Collaborative Innovation Department, United Imaging Healthcare, Shanghai, China
Presenting Author: Pan Wang

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References

1. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 2010;9(7):689-701. doi: 10.1016/S1474-4422(10)70104-6 [doi]
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3. Barisano G, Law M, Custer RM, Toga AW, Sepehrband F. Perivascular Space Imaging at Ultrahigh Field MR Imaging. Magn Reson Imaging Clin N Am. 2021;29(1):67-75. doi: 10.1016/j.mric.2020.09.005 [doi]
4. Staals J, Makin SD, Doubal FN, Dennis MS, Wardlaw JM. Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden. Neurology. 2014;83(14):1228-34. doi: 10.1212/WNL.0000000000000837 [doi]
5. Taoka T, Masutani Y, Kawai H, Nakane T, Matsuoka K, Yasuno F, Kishimoto T, Naganawa S. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. Jpn J Radiol. 2017;35(4):172-178. doi: 10.1007/s11604-017-0617-z [doi]
6. Zhang W, Zhou Y, Wang J, Gong X, Chen Z, Zhang X, Cai J, Chen S, Fang L, Sun J, Lou M. Glymphatic clearance function in patients with cerebral small vessel disease. Neuroimage. 2021;238:118257. doi: 10.1016/j.neuroimage.2021.118257 [doi]
7. Li H, Jacob MA, Cai M, Kessels RPC, Norris DG, Duering M, De Leeuw FE, Tuladhar AM. Perivascular Spaces, Diffusivity Along Perivascular Spaces, and Free Water in Cerebral Small Vessel Disease. Neurology. 2024;102(9):e209306. doi: 10.1212/WNL.0000000000209306 [doi]

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http://echo.ismrm.org/p/ISMRM2026/663-04-004