Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
564-03-014 ISMRM Abstract

3D Constrained qBOLD MRI Analysis of Cerebral Oxygenation and Perfusion Across the Healthy Adult Lifespan

Primary: Neuro - Aging
Secondary: Brain Function and fMRI - fMRI Acquisition
564-03-014 · fMRI: Development and Aging · Wednesday, 13 May, 1:40 PM–2:35 PM · Digital Posters Row E
Keywords: Quantitative BOLD Metabolic biomarker of healthy aging Quantitative Susceptibility Mapping (QSM) Cerebral Oxygen Metabolism Cerebral blood flow (CBF)
Accepted
Kathryn Jaroszynski 1,2, Sina Dindarian1, Hyunyeol Lee1,3, John Detre1,4, Felix W Wehrli1
1Department of Radiology, University of Pennsylvania, Philadelphia, United States of America
2Department of Bioengineering, University of Pennsylvania, Philadelphia, United States of America
3Kyungpook National University, Daegu, Korea, Republic of
4Department of Neurology, University of Pennsylvania, Philadelphia, United States of America
Presenting Author: Kathryn Jaroszynski

Synopsis

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References

1. 1. Cunnane SC, Trushina E, Morland C, et al. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov. Sep 2020;19(9):609-633. doi:10.1038/s41573-020-0072-x [doi]
2. 2. Catchlove SJ, Macpherson H, Hughes ME, Chen Y, Parrish TB, Pipingas A. An investigation of cerebral oxygen utilization, blood flow and cognition in healthy aging. PLoS One. 2018;13(5):e0197055. doi:10.1371/journal.pone.0197055 [doi]
3. 3. Ishii K, Kitagaki H, Kono M, Mori E. Decreased medial temporal oxygen metabolism in Alzheimer's disease shown by PET. J Nucl Med. Jul 1996;37(7):1159-65.
4. 4. Jiang D, Lin Z., Liu P., Sur S., Xu C., Hazel K., Pottanat G., Darrow J., Pillai J., Yasar S., Rosenberg P., Moghekar A., Albert M., Lu H. Brain Oxygen Extraction Is Differentially Altered by Alzheimer’s and Vascular Diseases. Journal of Magnetic Resonance Imaging. 2020;52(6)doi:10.1002/jmri.27264 [doi]
5. 5. Jiang D, Liu P, Lin Z, et al. MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe. Neuroimage. Feb 1 2023;266:119829. doi:10.1016/j.neuroimage.2022.119829 [doi]
6. 6. Taghvaei M, Dolui S, Sadaghiani S, et al. Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer's continuum. Alzheimers Dement. Jan 2025;21(1):e14382. doi:10.1002/alz.14382 [doi]
7. 7. Yang A, Zhuang H, Du L, et al. Evaluation of whole-brain oxygen metabolism in Alzheimer's disease using QSM and quantitative BOLD. Neuroimage. Nov 15 2023;282:120381. doi:10.1016/j.neuroimage.2023.120381 [doi]
8. 8. An H, Lin W. Quantitative measurements of cerebral blood oxygen saturation using magnetic resonance imaging. J Cereb Blood Flow Metab. Aug 2000;20(8):1225-36. doi:10.1097/00004647-200008000-00008 [doi]
9. 9. Cho J, Kee Y, Spincemaille P, et al. Cerebral metabolic rate of oxygen (CMRO(2) ) mapping by combining quantitative susceptibility mapping (QSM) and quantitative blood oxygenation level-dependent imaging (qBOLD). Magn Reson Med. Oct 2018;80(4):1595-1604. doi:10.1002/mrm.27135 [doi]
10. 10. Davis TL, Kwong KK, Weisskoff RM, Rosen BR. Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci U S A. Feb 17 1998;95(4):1834-9. doi:10.1073/pnas.95.4.1834 [doi]
11. 11. Lee H, Wehrli FW. Whole-brain 3D mapping of oxygen metabolism using constrained quantitative BOLD. Neuroimage. Apr 15 2022;250:118952. doi:10.1016/j.neuroimage.2022.118952 [doi]
12. 12. Zhang J, Liu T, Gupta A, Spincemaille P, Nguyen TD, Wang Y. Quantitative mapping of cerebral metabolic rate of oxygen (CMRO2 ) using quantitative susceptibility mapping (QSM). Magn Reson Med. Oct 2015;74(4):945-52. doi:10.1002/mrm.25463 [doi]
13. 13. Lee H, Wehrli FW. Alternating unbalanced SSFP for 3D R2' mapping of the human brain. Magn Reson Med. Dec 16 2021;85(5):2391-2402. doi:10.1002/mrm.28637 [doi]
14. 14. Lee H, Wehrli FW. Venous Cerebral Blood Volume Mapping in the Whole Brain Using Venous-Spin-Labeled 3D Turbo Spin Echo. Magn Reson Med. 2020;84(4):1991-2003. doi:https://doi.org/10.1002/mrm.28262 [doi]
15. 15. Xu F, Ge Y, Lu H. Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRI. Magn Reson Med. Jul 2009;62(1):141-8. doi:10.1002/mrm.21994 [doi]
16. 16. Folstein MF, Folstein,S.E., McHugh,P.R. "Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12(3)doi:10.1016/0022-3956(75)90026-6 [doi]
17. 17. Fischl B. FreeSurfer. Neuroimage. 2012;62(2):774-781.

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http://echo.ismrm.org/p/ISMRM2026/564-03-014