Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
366-04-002 ISMRM Abstract

Hyperpolarized dimethyl [1,4-13C2]fumarate as a probe of gluconeogenesis in the liver and kidney

Primary: Preclinical Animal & in vitro MR - Probes & Targets
Secondary: Preclinical Animal & in vitro MR - Small Animals
366-04-002 · Probes and Targets · Monday, 11 May, 2:45 PM–3:40 PM · Digital Posters Row G
Keywords: Liver Chronic Kidney Disease Hyperpolarized 13C Isotopomer analysis Gluconeogenesis
Accepted
Mai Huynh 1, Sung-Han Lin1, Xiaodong Wen1, Zohreh Erfani1, Jae Hong Park1,2,3,4, Zoltan Kovacs1,5, Craig Malloy1,2,6
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, United States of America
2Department of Radiology, University of Texas Southwestern Medical Center, Dallas, United States of America
3Department of Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, United States of America
4Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, United States of America
5Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, United States of America
6Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States of America
Presenting Author: Mai Huynh

Synopsis

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References

1. Gallagher, FA et al. Production of Hyperpolarized [1,4-13C2]Malate from [1,4-13C2]Fumarate Is a Marker of Cell Necrosis and Treatment Response in Tumors. Proc. Natl. Acad. Sci. U. S. A. 2009;106(47):19801-6.
2. Huynh, MT et al. Enhanced Solubility and Polarization of 13C-Fumarate with Meglumine Allows in vivo Detection of Gluconeogenic Metabolism in Kidneys. ACS Applied Materials and Interfaces, 2024, 16(29):37435-37444.
3. Rudakova, EV et al. Comparative analysis of esterase activities of human, mouse, and rat blood. Bull Exp Biol Med. 2011;152(1):73-5.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/366-04-002