Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
463-04-014 ISMRM Abstract

Fiber-specific estimation of intra-voxel T1 relaxation time in the human brain cortex with multidimensional MRI

Primary: Diffusion - Diffusion Modeling
Secondary: Neuro - Gray Matter
463-04-014 · Advanced Microstructural Imaging of White Matter and Traumatic Brain Injury · Tuesday, 12 May, 2:35 PM–3:30 PM · Digital Posters Row D
Keywords: Neurodegeneration Relaxometry Diffusion MRI Brain cortex Spherical deconvolution
Accepted
Ilse Peek 1, Cindy Cleypool2, Claire Mackaaij2, Annette Van der Toorn2,3, Rick M Dijkhuizen2, Alexander Leemans4,5, Alberto De Luca2,5,6
1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands
2UMC Utrecht, Utrecht, Netherlands
3Translational Neuroimaging group, Center for Image Sciences, UMC Utrecht, Utrecht, Netherlands
4UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, UMC Utrecht, Utrecht, Netherlands
5Brain Center, Department of Neurology and Neurosurgery, UMC Utrecht, Utrecht, Netherlands
6Image Sciences Institute, Division Imaging and Oncology, UMC Utrecht, Utrecht, Netherlands
Presenting Author: Ilse Peek

Synopsis

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References

1. M. Llorens-Martín et al., “Selective alterations of neurons and circuits related to early memory loss in Alzheimer’s disease,” Front Neuroanat, vol. 8, no. MAY, May 2014, doi: 10.3389/fnana.2014.00038. [doi]
2. S. Z. H. Kazmi and C. J. Wierenga, “Deep cortical layers are more vulnerable in Alzheimer’s disease,” Jul. 23, 2025, Cell Press. doi: 10.1016/j.neuron.2025.06.022. [doi]
3. J. Hutter et al., “Integrated and efficient diffusion-relaxometry using ZEBRA,” Sci Rep, vol. 8, no. 1, Dec. 2018, doi: 10.1038/s41598-018-33463-2. [doi]
4. M. Barakovic et al., “Resolving bundle-specific intra-axonal T2 values within a voxel using diffusion-relaxation tract-based estimation,” Neuroimage, vol. 227, Feb. 2021, doi: 10.1016/j.neuroimage.2020.117617. [doi]
5. S. De Santis, Y. Assaf, B. Jeurissen, D. K. Jones, and A. Roebroeck, “T1 relaxometry of crossing fibres in the human brain,” Neuroimage, vol. 141, pp. 133–142, Nov. 2016, doi: 10.1016/j.neuroimage.2016.07.037. [doi]
6. F. Guo, A. Leemans, M. A. Viergever, F. Dell’Acqua, and A. De Luca, “Generalized Richardson-Lucy (GRL) for analyzing multi-shell diffusion MRI data,” Neuroimage, vol. 218, Sep. 2020, doi: 10.1016/j.neuroimage.2020.116948. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/463-04-014