464-03-004 ISMRM Abstract

Probing altered cerebral 13C pyruvate metabolism in Amyotrophic Lateral Sclerosis

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)

Secondary: Neuro - Other Neurodegeneration

464-03-004 · Neurodegenerative Diseases · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row E

Keywords: X-nuclei Hyperpolarized 13C MRI Metabolic imaging Amyotrophic lateral sclerosis

Accepted

Alixander S Khan ¹, Mia Heintzelmann^1,2, Esben S Hansen¹, Nikolaj Bøgh¹, Nichlas Vous Christensen¹, Michael Væggemose^1,3, Lotte Bonde Bertelsen¹, Jakob U Bilcher⁴, Christoffer Laustsen¹

¹MR Research Centre, Aarhus University, Aarhus, Denmark

²Department of Neurology, Aarhus University Hospital, Aarhus N, Denmark

³GE Healthcare, Munich, Germany

⁴Department of Neurology, Aalborg University Hospital, Aalborg, Denmark

Presenting Author: Alixander S Khan

Synopsis

Motivation:

Goals:

Approach:

Results:

Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

References

1. Hu, J.Y., Vaziri, S., Bøgh, N., Kim, Y., Autry, A.W., Bok, R.A., Li, Y., Laustsen, C., Xu, D., Larson, P.E. and Chang, S., 2023. Investigating cerebral perfusion with high resolution hyperpolarized [1‐13C] pyruvate MRI. Magnetic reso-nance in medicine, 90(6), pp.2233-2241

2. Grist, J.T., Bøgh, N., Hansen, E.S., Schneider, A.M., Healicon, R., Ball, V., Miller, J.J., Smart, S., Couch, Y., Buchan, A.M. and Tyler, D.J., 2023. Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging. Scientific Reports, 13(1), p.1613.

3. Mikkelsen, E.F., Mariager, C.Ø., Nørlinger, T., Qi, H., Schulte, R.F., Jakobsen, S., Frøkiær, J., Pedersen, M., Stød-kilde-Jørgensen, H. and Laustsen, C., 2017. Hyperpolarized [1-13C]-acetate renal metabolic clearance rate map-ping. Scientific reports, 7(1), p.16002.

4. Vandoorne T, De Bock K, Van den Bosch L. Energy metabolism in ALS: an underappreciated opportunity? Acta Neuropathol. 2018; 135:489-509

5. Grist, J.T., Hansen, E.S., Sánchez‐Heredia, J.D., McLean, M.A., Tougaard, R., Riemer, F., Schulte, R.F., Kaggie, J.D., Ardenkjaer‐Larsen, J.H., Laustsen, C. and Gallagher, F.A., 2020. Creating a clinical platform for carbon‐13 studies using the sodium‐23 and proton resonances. Magnetic resonance in medicine, 84(4), pp.1817-1827.

6. Jerosch-Herold, M., 2010. Quantification of myocardial perfusion by cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 12(1), p.57.

7. Automated anatomical labelling atlas 3. Rolls, E. T., Huang, C. C., Lin, C. P., Feng, J., & Joliot, M., Neuroimage, 2020, 206, 116189, doi:10.1016/j.neuroimage.2019.116189 [doi]

8. Zejlon, C., Sennfält, S., Finnsson, J., Connolly, B., Petersson, S., Granberg, T. and Ingre, C., 2024. Motor band sign is specific for amyotrophic lateral sclerosis and corresponds to motor symptoms. Annals of Clinical and Translational Neurology, 11(5), pp.1280-1289.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/464-03-004