407-04-005 ISMRM Abstract

Increased Frequency of High-Intensity Physical Activity Associates with OA-like Changes to Femoral Bone Shape Following ACLR

Primary: Musculoskeletal - Bone

Secondary: Musculoskeletal - Osteoarthritis

407-04-005 · New Outcome Measures for Studying the Joint · Tuesday, 12 May, 4:00 PM–5:50 PM · Meeting Room 1.40

Keywords: Osteoarthritis Musculoskeletal MRI Activity Bone imaging Anterior Cruciate Ligament (ACL)

Accepted

Ashley A Williams ¹, Anthony A Gatti², Anoosha Pai S², Jade He¹, Constance R Chu¹

¹Department of Orthopaedic Surgery, Stanford Medicine, Stanford, United States of America

²Department of Radiology, Stanford Medicine, Stanford, United States of America

Presenting Author: Ashley A Williams

Synopsis

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References

1. Friedman JM, Su F, Zhang AL, et al. Patient-Reported Activity Levels Correlate With Early Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction. Am J Sports Med 2021; 49(2): 442-9.

2. Bowes MA, Kacena K, Alabas OA, et al. Machine-learning, MRI bone shape and important clinical outcomes in osteoarthritis: data from the Osteoarthritis Initiative. Ann Rheum Dis 2021; 80(4): 502-8. PMC7958089

3. Hunter D, Nevitt M, Lynch J, et al. Longitudinal validation of periarticular bone area and 3D shape as biomarkers for knee OA progression? Data from the FNIH OA Biomarkers Consortium. Ann Rheum Dis 2016; 75(9): 1607-14.

4. Neogi T, Bowes MA, Niu J, et al. Magnetic resonance imaging-based three-dimensional bone shape of the knee predicts onset of knee osteoarthritis: data from the osteoarthritis initiative. Arthritis Rheum 2013; 65(8): 2048-58. PMC3729737

5. Bowes MA, Lohmander LS, Wolstenholme CBH, Vincent GR, Conaghan PG, Frobell RB. Marked and rapid change of bone shape in acutely ACL injured knees - an exploratory analysis of the Kanon trial. Osteoarthritis Cartilage 2019; 27(4): 638-45.

6. Hassanlou L, Bowes MA, Turkiewicz A, et al. Bone shape changes over two years following acute anterior cruciate ligament injury: Reconstructed vs non-reconstructed knees. Osteoarthr Cartil Open 2025; 7(3): 100652. PMC12305710

7. Hunter DJ, Lohmander LS, Makovey J, et al. The effect of anterior cruciate ligament injury on bone curvature: exploratory analysis in the KANON trial. Osteoarthritis Cartilage 2014; 22(7): 959-68.

8. Gatti AA, Blankemeier L, Van Veen D, et al. ShapeMed-Knee: A Dataset and Neural Shape Model Benchmark for Modeling 3D Femurs. IEEE Trans Med Imaging 2025; 44(3): 1140-52. PMC11913582

9. Collins NJ, Misra D, Felson DT, Crossley KM, Roos EM. Measures of knee function: International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Knee Injury and Osteoarthritis Outcome Score (KOOS), Knee Injury and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS), Knee Outcome Survey Activities of Daily Living Scale (KOS-ADL), Lysholm Knee Scoring Scale, Oxford Knee Score (OKS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Activity Rating Scale (ARS), and Tegner Activity Score (TAS). Arthritis Care Res (Hoboken) 2011; 63 Suppl 11(0 11): S208-28. PMC4336550

10. Cameron KL, Peck KY, Thompson BS, Svoboda SJ, Owens BD, Marshall SW. Reference Values for the Marx Activity Rating Scale in a Young Athletic Population: History of Knee Ligament Injury Is Associated With Higher Scores. Sports health 2015; 7(5): 403-8. PMC4547111

11. Daniel DM, Stone ML, Dobson BE, Fithian DC, Rossman DJ, Kaufman KR. Fate of the ACL-injured patient. A prospective outcome study. Am J Sports Med 1994; 22(5): 632-44.

12. Williams AA, Koltsov JCB, Brett A, He J, Chu CR. Using 3D MRI Bone Shape to Predict Pre-Osteoarthritis of the Knee 2 Years After Anterior Cruciate Ligament Reconstruction. Am J Sports Med 2023; 51(14): 3677-86. PMC Journal – In Process

13. Goyal A, Belibi F, Sahani V, et al. Automating Imaging Biomarker Analysis for Knee Osteoarthritis Using an Open-Source MRI-Based Deep Learning Pipeline. MedRxiv 2025; preprint.

14. Pai S. A, Black M, Young K, et al. NEURAL SHAPE MODEL QUANTIFIES EARLY AND PROGRESSIVE BONE SHAPE CHANGES AFTER ACLR. 19th Annual International Workshop on Osteoarthritis Imaging. Cambridge, UK; 2025. p. Podium #S5.2.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/407-04-005