Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
331-01-001 / 331-01-001 ISMRM Abstract

Subacute Caudate Putamen Alteration Predicts Long-term Post-Stroke Outcomes Following Intranasal Hericium erinaceus Treatment

Primary: Neuro - Neurotherapeutics
Secondary: Preclinical Animal & in vitro MR - Biomarkers
331-01-001 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
331-01-001 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
Keywords: Diagnosis/Prediction Drugs Treatment Response Ischemic Stroke Preclinical Animal Models
Accepted
Ying-Wei Sung 1, Ting-Lin Tsai2, Pei-Chien Hsu2,3, Li-Ya Lee4, Chin-Chu Chen4, Jia-Jin Chen1, Bao-Yu Hsieh5, Yi-Hsuan Lee2,6, Yu-Chieh Jill Kao1
1Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
2Department and Institute of Physiology, National Yang Ming Chiao Tung University, Taipei, Taiwan
3Ph.D. Program of Interdisciplinary Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
4Biotech Research Institute, Grape King Bio Ltd., Taoyuan, Taiwan
5Department of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
6Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan
Presenting Author: Ying-Wei Sung

Synopsis

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References

1. Feigin VL, Brainin M, Norrving B, Martins SO, Pandian J, Lindsay P, et al. World Stroke Organization: Global Stroke Fact Sheet 2025. Int J Stroke 2025;20(2):132-44. https://doi.org/10.1177/17474930241308142 [doi]
2. French BR, Boddepalli RS, Govindarajan R. Acute Ischemic Stroke: Current Status and Future Directions. Mo Med 2016;113(6):480-6. https://www.ncbi.nlm.nih.gov/pubmed/30228538 [pmid]
3. Khoshnam SE, Winlow W, Farzaneh M, Farbood Y, Moghaddam HF. Pathogenic mechanisms following ischemic stroke. Neurol Sci 2017;38(7):1167-86. https://doi.org/10.1007/s10072-017-2938-1 [doi]
4. L L, X W, Z Y. Ischemia-reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies. Biochem Pharmacol (Los Angel) 2016;5(4). https://doi.org/10.4172/2167-0501.1000213 [doi]
5. Barthels D, Das H. Current advances in ischemic stroke research and therapies. Biochim Biophys Acta Mol Basis Dis 2020;1866(4):165260. https://doi.org/10.1016/j.bbadis.2018.09.012 [doi]
6. Farr TD, Wegener S. Use of magnetic resonance imaging to predict outcome after stroke: a review of experimental and clinical evidence. J Cereb Blood Flow Metab 2010;30(4):703-17. https://doi.org/10.1038/jcbfm.2010.5 [doi]
7. Tada H, Kawahara K, Osawa H, Song LT, Numazaki K, Kawai J, et al. Hericium erinaceus ethanol extract and ergosterol exert anti-inflammatory activities by neutralizing lipopolysaccharide-induced pro-inflammatory cytokine production in human monocytes. Biochem Biophys Res Commun 2022;636(Pt 2):1-9. https://doi.org/10.1016/j.bbrc.2022.10.090 [doi]
8. Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, et al. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci 2014;15(9):15073-89. https://doi.org/10.3390/ijms150915073 [doi]
9. Noh HJ, Yoon JY, Kim GS, Lee SE, Lee DY, Choi JH, et al. Benzyl alcohol derivatives from the mushroom Hericium erinaceum attenuate LPS-stimulated inflammatory response through the regulation of NF-kappaB and AP-1 activity. Immunopharmacol Immunotoxicol 2014;36(5):349-54. https://doi.org/10.3109/08923973.2014.947036 [doi]
10. Lin Y-J, Huang C-Y, Tsai BC-K, Kumar KA, Hsieh DJ-Y, Chiu P-L, et al. Alcoholic Hericium erinaceus mycelia extract induces SIRT-1/ERK-1/2 mediated autophagy to prevent accumulation and spreading of alpha-synuclein and amyloid-beta peptide on the A53T transgenic mice. Journal of Functional Foods 2023;110. https://doi.org/10.1016/j.jff.2023.105874 [doi]
11. Roda E, Priori EC, Ratto D, De Luca F, Di Iorio C, Angelone P, et al. Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging. Int J Mol Sci 2021;22(12). https://doi.org/10.3390/ijms22126379 [doi]
12. Ryu S, Kim HG, Kim JY, Kim SY, Cho KO. Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain. J Med Food 2018;21(2):174-80. https://doi.org/10.1089/jmf.2017.4006 [doi]
13. Kuo HC, Lu CC, Shen CH, Tung SY, Hsieh MC, Lee KC, et al. Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. J Transl Med 2016;14:78. https://doi.org/10.1186/s12967-016-0831-y [doi]
14. Hsu CH, Liao EC, Chiang WC, Wang KL. Antioxidative Activities of Micronized Solid-State Cultivated Hericium erinaceus Rich in Erinacine A against MPTP-Induced Damages. Molecules 2023;28(8). https://doi.org/10.3390/molecules28083386 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/331-01-001