Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
431-01-006 / 431-01-006 ISMRM Abstract

Differentiation of True Recurrence from Pseudoprogression in High-Grade Glioma Using 68Ga-PSMA-11 PET and ASL Perfusion MRI

Primary: Neuro - Tumors
Secondary: Neuro - Stroke and Cerebrovascular Disorders
431-01-006 · From Microstructure to Metabolism: Next-Generation MRI for Brain Tumors · Tuesday, 12 May, 8:20 AM–9:56 AM · Roof Terrace
431-01-006 · From Microstructure to Metabolism: Next-Generation MRI for Brain Tumors · Tuesday, 12 May, 8:20 AM–9:56 AM · Roof Terrace
Keywords: Glioma Pseudoprogression PET-MRI True Recurrence
Accepted
yuping han1, Jing Zhang 2,3,4,5, Zhuo Wang6, fei jia2,3,6, jingqi Jiang3,7
1Department of Nuclear Medicine, The Second Hospital of Lanzhou University, Lanzhou, China
2The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China
3Department of Magnetic Resonance, Lanzhou, China
4Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou, China, Department of Magnetic Resonance, Lanzhou, China
5Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou, China, Department of Magnetic Resonance, Lanzhou, China
6Department of Magnetic Resonance, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China
7Lanzhou University Second Hospital, Lanzhou, China
Presenting Author: Jing Zhang

Synopsis

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References

1. Louis DN, Perry A, Wesseling P, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021;23(8):1231-1251. doi:10.1093/neuonc/noab106 [doi]
2. Shi W, Wang X, Liu S, Zheng Z, Dong L, Jiang X. A multivariate retrospective analysis of high-grade gliomas: Survival and prognostic factors. Cancer Med. 2024;13(15):e7456. doi:10.1002/cam4.7456 [doi]
3. Pellerin A, Khalifé M, Sanson M, et al. Simultaneously acquired PET and ASL imaging biomarkers may be helpful in differentiating progression from pseudo-progression in treated gliomas. Eur Radiol. 2021;31(10):7395-7405. doi:10.1007/s00330-021-07732-0 [doi]
4. Henriksen OM, Hansen AE, Muhic A, et al. Diagnostic yield of simultaneous dynamic contrast-enhanced magnetic resonance perfusion measurements and [18F]FET PET in patients with suspected recurrent anaplastic astrocytoma and glioblastoma. Eur J Nucl Med Mol Imaging. 2022;49(13):4677-4691. doi:10.1007/s00259-022-05917-3 [doi]
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6. Song S, Cheng Y, Ma J, et al. Simultaneous FET-PET and contrast-enhanced MRI based on hybrid PET/MR improves delineation of tumor spatial biodistribution in gliomas: a biopsy validation study. Eur J Nucl Med Mol Imaging. 2020;47(6):1458-1467. doi:10.1007/s00259-019-04656-2 [doi]
7. Wang YL, Chen S, Xiao HF, et al. Differentiation between radiation-induced brain injury and glioma recurrence using 3D pCASL and dynamic susceptibility contrast-enhanced perfusion-weighted imaging. Radiother Oncol. 2018;129(1):68-74. doi:10.1016/j.radonc.2018.01.009 [doi]
8. Zhang J, Wang Y, Wang Y, et al. Perfusion magnetic resonance imaging in the differentiation between glioma recurrence and pseudoprogression: a systematic review, meta-analysis and meta-regression. Quant Imaging Med Surg. 2022;12(10):4805-4822. doi:10.21037/qims-22-32 [doi]
9. Van de Wiele C, Sathekge M, de Spiegeleer B, et al. PSMA expression on neovasculature of solid tumors. Histol Histopathol. 2020;35(9):919-927. doi:10.14670/HH-18-215 [doi]
10. Pruis IJ, van Dis V, Maas SLN, et al. PSMA radioligand uptake correlates with PSMA expression in high-grade glioma and brain metastasis: insights from a prospective PET-MRI guided multiregional biopsy study. Eur J Nucl Med Mol Imaging. Published online May 26, 2025. doi:10.1007/s00259-025-07338-4 [doi]

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http://echo.ismrm.org/p/ISMRM2026/431-01-006