Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-02-001 ISMRM Abstract

Neuromelanin MRI Reveals Spatial Signatures and Dopaminergic Coupling in Parkinson’s Progression

Primary: Neuro - Parkinson's Disease
Secondary: Neuro - Aging
369-02-001 · Imaging Parkinson’s Disease: Multimodal Biomarkers of Progression and Phenotype · Monday, 11 May, 9:15 AM–10:10 AM · Digital Posters Row J
Keywords: Parkinson's Disease Voxel-wise analysis PET-MRI Nigrostriatal Neuromelanin-Sensitive MRI
Accepted
Jose A. Pineda-Pardo 1, Miguel López-Aguirre1, Alvaro Sánchez-Ferro1, Raul Martínez-Fernández1, Mariana H. G. Monje1, Michele Matarazzo1, José Obeso1
1HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain
Presenting Author: Jose A. Pineda-Pardo

Synopsis

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References

1. Biondetti E, et al. The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson’s disease. Brain. 2021;144. doi: 10.1093/brain/awab191 [doi]
2. Madelung CF, et al. High-resolution mapping of substantia nigra in Parkinson’s disease using 7 tesla magnetic resonance imaging. NPJ Parkinson's Disease. 2025;11. doi: 10.1038/s41531-025-00972-7 [doi]
3. Xing Y, Sapuan A, Dineen RA, Auer DP. Life span pigmentation changes of the substantia nigra detected by neuromelanin-sensitive MRI. Movement Disorders. 2018;33. doi: 10.1002/mds.27502 [doi]
4. Pérot JB, et al. Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat model. Brain Communications. 2025;7. doi: 10.1093/braincomms/fcaf204 [doi]
5. Martín-Bastida A, et al. Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system. Brain. 2019;142. doi: 10.1093/brain/awz120 [doi]
6. Kaasinen V, et al. Striatal dopamine in Parkinson disease: A meta-analysis of imaging studies. Annals of Neurology. 2017;82. doi: 10.1002/ana.25103 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-02-001