Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
665-03-010 ISMRM Abstract

Global functional connectivity is altered in cognitively intact APOE ε4 carriers

Primary: Neuro - Alzheimer's Disease
Secondary: Brain Function and fMRI - Functional Connectivity
665-03-010 · fMRI: Applications in Neurology and Psychiatry III · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row F
Keywords: fMRI (resting state) Alzheimer's Disease Genetics Apolipoprotein E4 Healthy Adults
Accepted
Katherine A Koenig1, Sally Durgerian1, Mark Lowe 1, Frank DiFilippo1, Lynn M Bekris2, James B Leverenz3,4,5, Jagan Pillai5, Stephen M Rao5
1Diagnostic Radiology, Cleveland Clinic, Cleveland, United States of America
2Department of Laboratory Medicine and Pathology, University of Washington, Seattle, United States of America
3Geriatric Research, Education, and Clinical Center, VA-Puget Sound Health Care System, United States of America
4Department of Neurology, University of Washington, Seattle, United States of America
5Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, United States of America
Presenting Author: Mark Lowe

Synopsis

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References

1. Talwar P, Kushwaha S, Chaturvedi M, Mahajan V. Systematic Review of Different Neuroimaging Correlates in Mild Cognitive Impairment and Alzheimer's Disease. Clin Neuroradiol. 2021 Dec;31(4):953-967. doi: 10.1007/s00062-021-01057-7. [doi]
2. Foo H, Mather KA, Jiang J, Thalamuthu A, Wen W, Sachdev PS. Genetic influence on ageing-related changes in resting-state brain functional networks in healthy adults: A systematic review. Neurosci Biobehav Rev. 2020 Jun;113:98-110. doi: 10.1016/j.neubiorev.2020.03.011. [doi]
3. Beall E, Lowe MJ, Li M. A new model-based intrinsic connectivity measure: global functional connectivity. Proc 23rd ISMRM. 2014; #3046.
4. Lin, J, Shin, WS, Jones, SE, Koenig, KA, Lowe, MJ. Reproducibility Test of Global Functional Connectivity. Proc 30th ISMRM. 2021; #3133.
5. Beall EB, Lowe MJ. SimPACE: generating simulated motion corrupted BOLD data with synthetic-navigated acquisition for the development and evaluation of SLOMOCO: a new, highly effective slicewise motion correction. Neuroimage. 2014 Nov 1;101:21-34. doi: 10.1016/j.neuroimage.2014.06.038. [doi]
6. Lowe MJ, Sorenson JA. Spatially filtering functional magnetic resonance imaging data. Magn Reson Med. 1997 May;37(5):723-9. doi: 10.1002/mrm.1910370514. [doi]
7. Mirza-Davies A, Foley S, Caseras X, Baker E, Holmans P, Escott-Price V, Jones DK, Harrison JR, Messaritaki E. The impact of genetic risk for Alzheimer's disease on the structural brain networks of young adults. Front Neurosci. 2022 Nov 30;16:987677. doi: 10.3389/fnins.2022.987677. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/665-03-010