465-01-011 ISMRM Abstract

Hyperpolarized ¹³C-pyruvate first-pass metabolism reflects the first-pass perfusion pattern observed with [¹⁵O]H₂O PET/CT

Primary: Cardiovascular - Myocardium

Secondary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging

465-01-011 · Hyperpolarization: Novel Applications · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row F

Keywords: Ischemia Metabolism Perfusion Hyperpolarized 13C MRI Heart disease

Accepted

Niels A Jespersen ¹, Esben S Hansen², Steen H Joergensen, Christoffer Laustsen², Henrik Wiggers³, Lars C Gormsen⁴, Lotte Bonde Bertelsen², Rasmus S Tougaard⁵

¹Aarhus University, Aarhus, Denmark

²MR Research Centre, Aarhus University, Aarhus, Denmark

³Aarhus University Hospital, Aarhus N, Denmark

⁴The PET Centre, Aarhus University Hospital, Denmark

⁵Department of Cardiology, Aarhus University Hospital, Aarhus N, Denmark

Presenting Author: Niels A Jespersen

Synopsis

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References

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2. Apps, A. et al. Proof-of-principle demonstration of direct metabolic imaging following myocardial infarction using hyperpolarized 13C CMR. JACC Cardiovasc. Imaging 14, 1285–1288 (2021). PMID: 33582059 [pmid]

3. Joergensen, S. H. et al. Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-13C]pyruvate cardiovascular magnetic reso-nance imaging. J. Cardiovasc. Magn. Reson. 24, 34 (2022). PMID: 35658896 [pmid]

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6. PMID: 39210710 Vrints, C. et al. 2024 ESC Guidelines for the management of chronic coronary syndromes. Eur Heart J 45, 3415–3537 (2024). [pmid]

7. Rider, O. J. et al. Noninvasive in vivo assessment of cardiac metabolism in the healthy and diabetic human heart using hyperpolarized 13C MRI. Circ. Res. 126, 725–736 (2020). PMID: 32078413 [pmid]

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9. PMID: 29293983 Juárez-Orozco, L. E. et al. Quantitative myocardial perfusion evaluation with positron emission tomography and the risk of cardiovascular events in patients with coronary artery disease: a sys-tematic review of prognostic studies. Eur. Heart J. Cardiovasc. Imaging 19, 1179–1187 (2018). [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/465-01-011