Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
370-04-035 ISMRM Abstract

Perfusion Measurements in Gliomas and Cognitive Decline Continuum in Alzheimer’s Disease Using BBB-ASL MRI

Primary: Neuro - Tumors
Secondary: Neuro - Dementia
370-04-035 · Analysis in Neurodegenerative Disease · Monday, 11 May, 1:50 PM–2:45 PM · Traditional Posters | Exhibition Hall
Keywords: Permeability Dementia Blood brain barrier Brain Tumor Imaging Perfusion MRI
Accepted
Gülce Turhan 1, Beatriz E Padrela2,3, Ayse Irem Cetin1, Amnah Mahroo4,5, Simon Konstandin4, Daniel Christopher Hoinkiss4, Nora-Josefin Breutigam4, Vera C Keil2, Ayca Ersen Danyeli6,7, Koray Özduman6,8, Atle Bjørnerud9, Sandra Tecelão10, Per Selnes11, Oliver M Geier9, Klaus Eickel4,12, Henk J Mutsaerts2,3,13, Tormod Fladby10,14, Matthias Günther4,15,16, Jan Petr2,17, Alp Dinçer6,18, Esin Ozturk Isik1,6
1Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey
2Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
3Amsterdam Neuroscience, Amsterdam, Netherlands
4Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany
5University Health Network, Toronto, Canada
6Brain Tumor Research Group, Acibadem University, Istanbul, Turkey
7Department of Pathology, Acibadem University, Istanbul, Turkey
8Department of Neurosurgery, Acibadem University, Istanbul, Turkey
9Department of Physics, University of Oslo, Oslo, Norway
10Department of Neurology, Akershus University Hospital, Oslo, Norway
11Department of Research, Akershus University Hospital, Oslo, Norway
12Bremerhaven University of Applied Sciences, Bremerhaven, Germany
13Radiology and Nuclear Medicine,, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
14University of Oslo, Oslo, Norway
15mediri GmbH, Heidelberg, Germany
16University of Bremen, Bremen, Germany
17Helmholtz-Zentrum Dresden Rossendorf, Germany
18Department of Radiology, Acibadem University, Istanbul, Turkey
Presenting Author: Gülce Turhan

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References

1. Halilibrahimoğlu H, Polat K, Keskin S, et al.: Associating IDH and TERT mutations in glioma with diffusion anisotropy in normal-appearing white matter. AJNR Am J Neuroradiol 2023; 44:553–561.
2. Lorenzini L, Ansems LT, Lopes Alves I, et al.: Regional associations of white matter hyperintensities and early cortical amyloid pathology. Brain Commun 2022; 4:fcac150.
3. Turhan G, Çetin Aİ, Padrela B, et al.: Perfusion and Time of Exchange Measurements in IDH Mutational Subgroups of Gliomas Using BBB-ASL. International Society for Magnetic Resonance in Medicine. Honolulu, Hawai'i, USA. May 10-15, 2025 (#0880)
4. Padrela B, Mahroo A, Tee M, et al.: Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol. BMJ Open 2024; 14:e081635.
5. Sun X, Salat D, Upchurch K, et al.: Destruction of white matter integrity in patients with mild cognitive impairment and Alzheimer disease. J Investig Med 2014; 62:927–933.
6. Mahroo A, Buck MA, Huber J, et al.: Robust multi-TE ASL-based blood-brain barrier integrity measurements. Front Neurosci 2021; 15:719676.
7. Mutsaerts HJMM, Petr J, Groot P, et al.: ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies. Neuroimage 2020; 219:117031.
8. Woolrich MW, Chiarelli P, Gallichan D, Perthen J, Liu TT: Bayesian inference of hemodynamic changes in functional arterial spin labeling data. Magn Reson Med 2006; 56:891–906.
9. Gaser C, Dahnke R, Thompson PM, Kurth F, Luders E. CAT: A computational anatomy toolbox for the analysis of structural MRI data. Gigascience. 2024;13. doi10.1093/gigascience/giae049 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/370-04-035