Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-03-008 ISMRM Abstract

Non‑Invasive Assessment of Glymphatic Dysfunction in Middle Cerebral Artery Stenosis based on DTI-ALPS and ro-ALPS

Primary: Diffusion - DWI/DTI/DKI
Secondary: Neuro - Blood Vessels
663-03-008 · Glymphatic System Imaging: From Neurofluid Transport to Neurodegeneration · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row D
Keywords: Blood vessels Glymphatic system Cerebral blood flow 3.0T magnetic resonance imaging DTI-ALPS index
Accepted
yidi zhu 1, Luoyu Wang2, Liqing Zhang3, Xue Tang4, Maoling Liu1, Qingqing Wen5, Darong Zhu6, xiufang xu1, Zhongxiang Ding3,7
1Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China
2School of Biomedical Engineering, ShanghaiTech University, Shanghai, China
3Hangzhou First People's Hospital, Hangzhou, China
4Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, China
5MR Research, Beijing, China
6Department of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China
7Department of Radiology, Affiliated Hangzhou First People's Hospital,Westlake University School of Medicine,Hangzhou,China.hangzhoudzx73@126.com., China
Presenting Author: yidi zhu

Synopsis

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References

1. Zhang DF, Chen YC, Chen H, et al. A high-resolution MRI study of relationship between remodeling patterns and ischemic stroke in patients with atherosclerotic middle cerebral artery stenosis. Front Aging Neurosci. 2017;9:140. doi:10.3389/fnagi.2017.00140 [doi]
2. Wang Y, Zhao X, Liu L, et al. Prevalence and Outcomes of Symptomatic Intracranial Large Artery Stenoses and Occlusions in China: The Chinese Intracranial Atherosclerosis (CICAS) Study. Stroke. 2014;45(3):663-669. doi:10.1161/STROKEAHA.113.003508 [doi]
3. Mestre H, Tithof J, Du T, et al. Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nat Commun. 2018;9(1):4878. doi:10.1038/s41467-018-07318-3 [doi]
4. Iliff JJ, Wang M, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med. 2012;4(147). doi:10.1126/scitranslmed.3003748 [doi]
5. Taoka T, Masutani Y, Kawai H, et al. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases. Jpn J Radiol. 2017;35(4):172-178. doi:10.1007/s11604-017-0617-z [doi]
6. Ueda D, Mitsuyama Y, Takita H, et al. Diagnostic performance of ChatGPT from patient history and imaging findings on the diagnosis please quizzes. Radiology. 2023;308(1). doi:10.1148/radiol.231040 [doi]
7. Tournier JD, Smith R, Raffelt D, et al. MRtrix3: a fast, flexible and open software framework for medical image processing and visualisation. Neuroimage. 2019;202:116137. doi:10.1016/j.neuroimage.2019.116137 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/663-03-008