Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
570-11-248 ISMRM Abstract

DTI tractography reveals HIV exposure-related changes in microstructural integrity detectable at birth

Primary: Diffusion - Tractography
Secondary: Diffusion - Microstructure
570-11-248 · Pediatric MR Imaging in Practice · Wednesday, 13 May, 4:55 PM–5:50 PM · Traditional Posters | Exhibition Hall
Keywords: HIV exposure Diffusion Tensor Imaging (DTI) White matter tracts Neonatal brain development Antiretroviral drugs
Accepted
Praise R Matsekete 1, Ndivhuwo Magondo1, Barbara Laughton2, Andre J van der Kouwe1,3, Ernesta Meintjes1,4,5, Fleur L Warton1,5
1Biomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
2Family Centre for Research with Ubuntu, Department of Paediatrics &Child Health, Stellenbosch University, Stellenbosch, South Africa
3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
4Cape Universities Body Imaging Centre, University of Cape Town, South Africa
5Neuroscience Institute, University of Cape Town, South Africa
Presenting Author: Praise R Matsekete

Synopsis

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References

1. Young, J. M., Bitnun, A., Read, S. E. & Smith, M. Lou. Neurodevelopment of HIV-Exposed Uninfected Children Compared With HIV-Unexposed Uninfected Children During Early Childhood. Dev Psychol 58, 551–559 (2022).
2. Benki-Nugent, S. F. et al. Lower Neurocognitive Functioning in HIV-Exposed Uninfected Children Compared with That in HIV-Unexposed Children. J Acquir Immune Defic Syndr (1988) 89, (2022).
3. Madlala, H. P., Myer, L., Malaba, T. R. & Newell, M.-L. Neurodevelopment of HIV-exposed uninfected children in Cape Town, South Africa. PLoS One 15, (2020).
4. Ntozini, R. et al. Early child development in children who are HIV-exposed uninfected compared to children who are HIV- unexposed: observational sub-study of a cluster-randomized trial in rural Zimbabwe. https://doi.org/10.1002/jia2.25456 (2020). [doi]
5. Springer, P. E. et al. Neurodevelopmental outcome of HIV-exposed but uninfected infants in the Mother and Infants Health Study, Cape Town, South Africa. Tropical Medicine and International Health 23, 69–78 (2018).
6. le Roux, S. M. et al. HIV Viremia During Pregnancy and Neurodevelopment of HIV-Exposed Uninfected Children in the Context of Universal Antiretroviral Therapy and Breastfeeding: A Prospective Study. Pediatric Infectious Disease Journal 38, 70–75 (2019).
7. McHenry, M. S. et al. In utero exposure to HIV and/or antiretroviral therapy: a systematic review of preclinical and clinical evidence of cognitive outcomes. J Int AIDS Soc 22, (2019).
8. Tran, L. T. et al. White Matter Microstructural Integrity and Neurobehavioral Outcome of HIV-Exposed Uninfected Neonates. Medicine (United States) 95, (2016).
9. Jahanshad, N. et al. Brain Imaging and Neurodevelopment in HIV-uninfected Thai Children Born to HIV-infected Mothers. Pediatric Infectious Disease Journal 34, (2015).
10. Magondo, N. The influence of maternal HIV and ART exposure on neonate brain white matter integrity and organisation. (University of Cape Town, Cape Town, 2022).
11. Magondo, N. et al. Distinct alterations in white matter properties and organization related to maternal treatment initiation in neonates exposed to HIV but uninfected. Sci Rep 14, (2024).
12. Mberi, F. et al. Ongoing white matter alterations in HIV infected and HIV exposed children: A DTI study at 9 years. J Int AIDS Soc 21, (2018).
13. Ibrahim, A. et al. Maternal ART throughout gestation prevents caudate volume reductions in neonates who are HIV exposed but uninfected. Front Neurosci 17, (2023).
14. Cox, R. W. AFNI: Software for Analysis and Visualization of Functional Magnetic Resonance Neuroimages. Computers and Biomedical Research 29, 162–173 (1996).
15. Pierpaoli, C. et al. TORTOISE: an integrated software package for processing of diffusion MRI data. in ISMRM 18th annual meeting (2010).
16. Zöllei, L., Iglesias, J. E., Ou, Y., Grant, P. E. & Fischl, B. Infant FreeSurfer: An automated segmentation and surface extraction pipeline for T1-weighted neuroimaging data of infants 0–2 years. Neuroimage 218, (2020).
17. Bokde, A. L. W. et al. Reliable manual segmentation of the frontal, parietal, temporal, and occipital lobes on magnetic resonance images of healthy subjects. Brain Research Protocols 14, (2005).
18. Bokde, A. L. W. et al. A new rapid landmark-based regional MRI segmentation method of the brain. J Neurol Sci 194, (2002).
19. Zöllei, L., Iglesias, J. E., Ou, Y., Grant, P. E. & Fischl, B. Infant FreeSurfer: An automated segmentation and surface extraction pipeline for T1-weighted neuroimaging data of infants 0–2 years. Neuroimage 218, (2020).
20. R Core Team. R core team (2021). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL http://www. R-project. org Preprint at (2021).
21. Jankiewicz, M. et al. White matter abnormalities in children with HIV infection and exposure. Front Neuroanat 11, (2017).
22. Saad, Z. S. & Reynolds, R. C. SUMA. NeuroImage vol. 62 768–773 Preprint at https://doi.org/10.1016/j.neuroimage.2011.09.016 (2012). [doi]

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http://echo.ismrm.org/p/ISMRM2026/570-11-248