Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
406-01-006 ISMRM Abstract

Mapping Glutamate Responses to Visual Stimulation with Functional Magnetic Resonance Spectroscopic Imaging

Accepted
Zhiwei Huang 1, Andre Doring1, uzay emir2,3,4,5, Antonia Kaiser1, Martin Zach1, Penghui Du1, Michael Unser1,6, Dimitrios Karampinos1,7, Lijing Xin1
1CIBM Center for Biomedical Imaging, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
2University of North Carolina at Chapel Hill, Chapel Hill, United States of America
3Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
4Lampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
5Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
6Biomedical Imaging Group, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
7Laboratory of Magnetic Resonance Imaging Systems and Methods, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Presenting Author: Zhiwei Huang

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Stanley, J. A.; Raz, N. Functional Magnetic Resonance Spectroscopy: The “New” MRS for Cognitive Neuroscience and Psychiatry Research. Front. Psychiatry 2018, 9. https://doi.org/10.3389/fpsyt.2018.00076. [doi]
2. Mullins, P. G. Towards a Theory of Functional Magnetic Resonance Spectroscopy (fMRS): A Meta-Analysis and Discussion of Using MRS to Measure Changes in Neurotransmitters in Real Time. Scand. J. Psychol. 2018, 59 (1), 91–103. https://doi.org/10.1111/sjop.12411. [doi]
3. Mangia, S.; Tkác, I.; Gruetter, R.; Van de Moortele, P.-F.; Maraviglia, B.; Uğurbil, K. Sustained Neuronal Activation Raises Oxidative Metabolism to a New Steady-State Level: Evidence from 1H NMR Spectroscopy in the Human Visual Cortex. J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab. 2007, 27 (5), 1055–1063. https://doi.org/10.1038/sj.jcbfm.9600401. [doi]
4. Boillat, Y.; Xin, L.; van der Zwaag, W.; Gruetter, R. Metabolite Concentration Changes Associated with Positive and Negative BOLD Responses in the Human Visual Cortex: A Functional MRS Study at 7 Tesla. J. Cereb. Blood Flow Metab. 2020, 40 (3), 488–500. https://doi.org/10.1177/0271678X19831022. [doi]
5. Lin, Y.; Stephenson, M. C.; Xin, L.; Napolitano, A.; Morris, P. G. Investigating the Metabolic Changes Due to Visual Stimulation Using Functional Proton Magnetic Resonance Spectroscopy at 7 T. J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab. 2012, 32 (8), 1484–1495. https://doi.org/10.1038/jcbfm.2012.33. [doi]
6. Ip, I. B.; Berrington, A.; Hess, A. T.; Parker, A. J.; Emir, U. E.; Bridge, H. Combined fMRI-MRS Acquires Simultaneous Glutamate and BOLD-fMRI Signals in the Human Brain. NeuroImage 2017, 155, 113–119. https://doi.org/10.1016/j.neuroimage.2017.04.030. [doi]
7. Bednarik, P.; Goranovic, D.; Svatkova, A.; Niess, F.; Hingerl, L.; Strasser, B.; Deelchand, D. K.; Spurny-Dworak, B.; Krssak, M.; Trattnig, S.; Hangel, G.; Scherer, T.; Lanzenberger, R.; Bogner, W. 1H Magnetic Resonance Spectroscopic Imaging of Deuterated Glucose and of Neurotransmitter Metabolism at 7 T in the Human Brain. Nat. Biomed. Eng. 2023, 7 (8), 1001–1013. https://doi.org/10.1038/s41551-023-01035-z. [doi]
8. Schaller, B.; Mekle, R.; Xin, L.; Kunz, N.; Gruetter, R. Net Increase of Lactate and Glutamate Concentration in Activated Human Visual Cortex Detected with Magnetic Resonance Spectroscopy at 7 Tesla. J. Neurosci. Res. 2013, 91 (8), 1076–1083. https://doi.org/10.1002/jnr.23194. [doi]
9. Marques, J. P.; Kober, T.; Krueger, G.; van der Zwaag, W.; Van de Moortele, P.-F.; Gruetter, R. MP2RAGE, a Self Bias-Field Corrected Sequence for Improved Segmentation and T1-Mapping at High Field. NeuroImage 2010, 49 (2), 1271–1281. https://doi.org/10.1016/j.neuroimage.2009.10.002. [doi]
10. Huang, Z.; Emir, U.; Döring, A.; Klauser, A.; Xiao, Y.; Widmaier, M.; Xin, L. Rosette Spectroscopic Imaging for Whole-Brain Slab Metabolite Mapping at 7T: Acceleration Potential and Reproducibility. Hum. Brain Mapp. 2025, 46 (4), e70176. https://doi.org/10.1002/hbm.70176. [doi]
11. Andre, D. (ISMRM 2025) Functional Glutamate and GABA Response Maps to Visual Stimulation by Functional Magnetic Resonance Spectroscopic Imaging; Hawaii, 2025.
12. Jenkinson, M.; Beckmann, C. F.; Behrens, T. E. J.; Woolrich, M. W.; Smith, S. M. FSL. NeuroImage 2012, 62 (2), 782–790. https://doi.org/10.1016/j.neuroimage.2011.09.015. [doi]
13. Provencher, S. W. Automatic Quantitation of Localized in Vivo 1H Spectra with LCModel. NMR Biomed. 2001, 14 (4), 260–264. https://doi.org/10.1002/nbm.698. [doi]
14. Schaller, B.; Xin, L.; O’Brien, K.; Magill, A. W.; Gruetter, R. Are Glutamate and Lactate Increases Ubiquitous to Physiological Activation? A (1)H Functional MR Spectroscopy Study during Motor Activation in Human Brain at 7Tesla. NeuroImage 2014, 93 Pt 1, 138–145. https://doi.org/10.1016/j.neuroimage.2014.02.016. [doi]
15. Beckmann, C. F.; Smith, S. M. Probabilistic Independent Component Analysis for Functional Magnetic Resonance Imaging. IEEE Trans. Med. Imaging 2004, 23 (2), 137–152. https://doi.org/10.1109/TMI.2003.822821. [doi]
16. Serafini S, Steury K, Richards T, Corina D, Abbott R, Dager SR, Berninger V. Comparison of fMRI and PEPSI during language processing in children. Magn Reson Med. 2001 Feb;45(2):217-25. doi: 10.1002/1522-2594(200102)45:2<217::AID-MRM1030>3.0.CO;2-3. [doi]
17. Seuwen A, Schroeter A, Grandjean J, Schlegel F, Rudin M. Functional spectroscopic imaging reveals specificity of glutamate response in mouse brain to peripheral sensory stimulation. Sci Rep. 2019 Jul 22;9(1):10563. doi: 10.1038/s41598-019-46477-1. [doi]
18. Bozymski B, Shen X, Özen A, Chiew M, Thomas MA, Clarke WT, Sawiak S, Dydak U, Emir U. Feasibility and comparison of 3D modified rosette ultra-short echo time (PETALUTE) with conventional weighted acquisition in 31P-MRSI. Sci Rep. 2025 Feb 22;15(1):6465. doi: 10.1038/s41598-025-90630-y. [doi]

Cite this abstract