Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
601-02-007 ISMRM Abstract

Assessing T2 relaxation time in lower limb muscles in adults with and without sarcopenia

Primary: Musculoskeletal - Muscle
Secondary: Contrast Mechanisms - Relaxometry
601-02-007 · Muscle MRI in Health and Disease: From Standardization to Application · Thursday, 14 May, 1:40 PM–3:30 PM · Hall 1A
Keywords: Translational Studies Aging T2 mapping Extended Phase Graph Sarcopenia
Accepted
Matthew Birkbeck 1,2, Karen Suetterlin3,4,5, Christopher Hurst4,5, Claire McDonald4,5, Susan Hillman4,5, Avan A Sayer4,5, Rachel Cooper4,5, Miles D Witham4,5, Kieren G Hollingsworth6
1Newcastle Magnetic Resonance Centre, Translational and Clinical Research Institue, Newcastle University, Newcastle upon Tyne, United Kingdom
2Northern Medical Physics and Clinical Engineering, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
3Neurophysiology, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
4AGE Research Group, Translational and Clinical Research Insitute, Newcastle University, Newcastle upon Tyne, United Kingdom
5NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, United Kingdom
6Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
Presenting Author: Matthew Birkbeck

Synopsis

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References

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2. Welle S. Cellular and molecular basis of age-related sarcopenia. Can J Appl Physiol. 2002 Feb;27(1):19-41. doi: 10.1139/h02-002. PMID: 11880689. [doi] [pmid]
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6. Marty B, Baudin PY, Reyngoudt H, Azzabou N, Araujo EC, Carlier PG, de Sousa PL. Simultaneous muscle water T2 and fat fraction mapping using transverse relaxometry with stimulated echo compensation. NMR Biomed. 2016 Apr;29(4):431-43. doi: 10.1002/nbm.3459. Epub 2016 Jan 27. PMID: 26814454. [doi] [pmid]
7. McDonald C, Alderson C, Birkbeck MG, Del Din S, Gorman GS, Hollingsworth KG, Kirk C, Massarella C, Rochester L, Tuppen HAL, Warren C, Sayer AA, Witham MD. Effect of acipimox on skeletal muscle biochemistry, structure and function in older people with probable sarcopenia: an experimental medicine study. Geroscience. 2025 Aug;47(4):6065-6078. doi: 10.1007/s11357-025-01606-9. Epub 2025 Mar 18. PMID: 40100528; PMCID: PMC12397013. [doi] [pmid]
8. Dodds RM, Hurst C, Hillman SJ, Davies K, Roberts L, Aspray TJ, Granic A, Sayer AA. Advancing our understanding of skeletal muscle across the lifecourse: Protocol for the MASS_Lifecourse study and characteristics of the first 80 participants. Exp Gerontol. 2022 Sep;166:111884. doi: 10.1016/j.exger.2022.111884. Epub 2022 Jul 1. PMID: 35788023. [doi] [pmid]
9. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jan 1;48(1):16-31. doi: 10.1093/ageing/afy169. Erratum in: Age Ageing. 2019 Jul 1;48(4):601. doi: 10.1093/ageing/afz046. PMID: 30312372; PMCID: PMC6322506. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/601-02-007