Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
560-02-014 ISMRM Abstract

Ex vivo QSM of whole human brain hemispheres at 160 µm resolution applied to frontotemporal lobar degeneration

Primary: Acquisition & Reconstruction - Pulse Sequence Design: Neuro
Secondary: Contrast Mechanisms - Susceptibility/QSM
560-02-014 · New Developments in QSM II · Wednesday, 13 May, 9:15 AM–10:10 AM · Digital Posters Row A
Keywords: Acquisition Methods Neurodegeneration Pulse Sequence Design Quantitative Susceptibility Mapping (QSM) Ex vivo MRI
Accepted
Shraddha R Pandey 1, Alexandra G Roberts2,3, Winifred Trotman1, Hamsanandini Radhakrishnan1, Christopher A Olm1, Philip Cook1, Gabor Mizsei1, Karthik Prabhakaran1, James C Gee1, Edward Lee4, Paul A Yushkevich1, Corey McMillan1, David J Irwin1, M. Dylan Tisdall1
1University of Pennsylvania, Philadelphia, United States of America
2Electrical & Computer Engineering, Cornell University, Ithaca, United States of America
3Radiology, Weill Cornell Medicine, New York, United States of America
4Department of Pathology and Laboratory Medicine, Perelman School of Medicine,, University of Pennsylvania, Philadelphia, United States of America
Presenting Author: Shraddha R Pandey

Synopsis

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References

1. Tisdall MD, Ohm DT, Lobrovich R, Das SR, Mizsei G, Prabhakaran K, Ittyerah R, Lim S, McMillan CT, Wolk DA, Gee J, Trojanowski JQ, Lee EB, Detre JA, Yushkevich P, Grossman M, Irwin DJ. Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology. NeuroImage: Clinical. 2022;33:102913.
2. Giannini LAA, Bulk M, Kenkhuis B, Rajicic A, Melhem S, Hegeman‐Kleinn I, Bossoni L, Suidgeest E, Dopper EGP, Van Swieten JC, Van Der Weerd L, Seelaar H. Cortical iron accumulation in MAPT ‐ and C9orf 72 ‐associated frontotemporal lobar degeneration. Brain Pathology. 2023 July;33(4):e13158.
3. QSM Consensus Organization Committee, Bilgic B, Costagli M, Chan K, Duyn J, Langkammer C, Lee J, Li X, Liu C, Marques JP, Milovic C, Robinson SD, Schweser F, Shmueli K, Spincemaille P, Straub S, Van Zijl P, Wang Y, ISMRM Electro‐Magnetic Tissue Properties Study Group. Recommended implementation of quantitative susceptibility mapping for clinical research in the brain: A consensus of the ISMRM electro‐magnetic tissue properties study group. Magnetic Resonance in Med. 2024 May;91(5):1834–1862.
4. Chan, Kwok-Shing, and José P. Marques. "SEPIA-Susceptibility mapping pipeline tool for phase images." bioRxiv (2020): 2020-07.
5. Liu, Jing, et al. "Morphology enabled dipole inversion for quantitative susceptibility mapping using structural consistency between the magnitude image and the susceptibility map." Neuroimage 59.3 (2012): 2560-2568.
6. Liu, Tian, et al. "A novel background field removal method for MRI using projection onto dipole fields." NMR in Biomedicine 24.9 (2011): 1129-1136.
7. Roberts AG, Romano DJ, Şişman M, Dimov AV, Nguyen TD, Kovanlikaya I, Gauthier SA, Wang Y, Spincemaille P. Maximum spherical mean value filtering for whole‐brain QSM. Magnetic Resonance in Med. 2024 Apr;91(4):1586–1597.
8. Karsa, Anita, Shonit Punwani, and Karin Shmueli. "High repeatability of quantitative susceptibility mapping (QSM) in the head and neck with a view to detecting hypoxic cancer sites." International Society for Magnetic Resonance in Medicine (ISMRM), 2019.
9. Li, Jianqi, Shixin Chang, Tian Liu, Hongwei Jiang, Fang Dong, Mengchao Pei, Qianfeng Wang, and Yi Wang. 2015. 'Phase-corrected bipolar gradients in multi-echo gradient-echo sequences for quantitative susceptibility mapping', Magnetic Resonance Materials in Physics, Biology and Medicine, 28: 347-55.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/560-02-014