Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
504-02-008 ISMRM Abstract

Detecting Neuroinflammation in the Human Brain Using SANDI: Evidence from an LPS Challenge Model

Primary: Neuro - Neuroinflammation
Secondary: Diffusion - Microstructure
504-02-008 · Probing Brain Microstructure with Water: Applications · Wednesday, 13 May, 8:20 AM–10:10 AM · Ballroom East
Keywords: Inflammation Diffusion MRI modelling Microglia
Accepted
George Tackley1, Natalie Jones1, Maryam Afzali1,2,3, Kadir Şimşek1, Andrè Döring4, Jonathan Underwood5,6, James Coulson7, Claire L MacIver7, Yaseen Rehman8, Ella Kugele9, Sara Obudi7, Marco Palombo1,10, Neil A Harrison1, Mara Cercignani 1
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
2Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, Leeds, United Kingdom
3Division of Cardiovascular Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom
4CIBM Center for Biomedical Imaging, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
5School of Medicine, Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom
6Department of Infectious Diseases, Cardiff and Vale University Health Board, Cardiff, United Kingdom
7School of Medicine, Cardiff University, Cardiff, United Kingdom
8School of Pharmacy, Cardiff University, Cardiff, United Kingdom
9School of Psychology, Cardiff University, Cardiff, United Kingdom
10School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom
Presenting Author: Mara Cercignani

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Khandaker, G., Harrison, N., Bullmore, E., Dantzer, R. (Eds.), 2021. Textbook of Immunopsychiatry. Cambridge University Press. Doi: 10.1017/9781108539623 [doi]
2. Critchley, H.D., Harrison, N.A. Visceral Influences on Brain and Behavior. Neuron, 2013;10.1016/j.neuron.2013.02.00
3. Paolicelli, R.C., Sierra, A., Stevens. B., et al. Microglia states and nomenclature: A field at its crossroads. Neuron, 2022; 110:3458-3483. doi: 10.1016/j.neuron.2022.10.020. [doi]
4. De Marco, R., Ronen, I., Branzoli, F., et al. Diffusion-weighted MR spectroscopy (DW-MRS) is sensitive to LPS- induced changes in human glial morphometry: A preliminary study Brain, Behavior, and Immunity, 2022; 99: 256-265. doi.org/10.1016/j.bbi.2021.10.005. [doi]
5. Palombo, M., Ianus, A., Guerreri, M., et al. SANDI: A compartment-based model for non-invasive apparent soma and neurite imaging by diffusion MRI. Neuroimage, 2020; 215:116835. doi: 10.1016/j.neuroimage.2020.116835. [doi]
6. Alexander DC, Zikic D, Ghosh A, et al. Image quality transfer and applications in diffusion MRI. Neuroimage, 2017;152:283-298. doi: 10.1016/j.neuroimage.2017.02.089. [doi]
7. Lupi E, Palesi F, McNabb C, Laguna PL, Figini M, Alexander DC, D’Angelo E, Wheeler-Kingshott CA, Cercignani M, Palombo M. Accurate super-resolution of diffusion MRI data at ultra-strong gradients and varying diffusion time using Image Quality Transfer. ISMRM 2025, #0321

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/504-02-008